Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects.
Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects.
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DOI：
10.3389/fnins.2018.00037
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发表时间：
2018
影响因子：
4.3
通讯作者：
De Felice FG
中科院分区：
文献类型：
--
作者：
Frozza RL;Lourenco MV;De Felice FG
阿尔茨海默病（AD）是老年痴呆症中最常见的形式，到本世纪中叶将变得更加普遍，构成一个重大的全球健康问题，对个人和社会都有巨大影响。尽管过去几十年的科学突破扩大了我们对阿尔茨海默病的细胞和分子基础的认识，但有效阻止疾病进展的治疗方法仍然缺乏，需要集中精力解决这一公共卫生挑战。由于阿尔茨海默病通常被认为是一种记忆疾病，研究主要集中在调查与记忆相关的大脑缺陷。然而，令人信服的证据表明，在疾病过程中，与记忆无关的其他大脑区域也受到了影响。在这篇综述中，我们概述了目前对AD的主要病理生理机制及其临床表现的理解。我们还强调了如何考虑阿尔茨海默病发病机制的复杂性，并探索重新定位的药物方法可以为阿尔茨海默病的新疗法的发展铺平道路。
Alzheimer's disease (AD), the most common form of dementia in late life, will become even more prevalent by midcentury, constituting a major global health concern with huge implications for individuals and society. Despite scientific breakthroughs during the past decades that have expanded our knowledge on the cellular and molecular bases of AD, therapies that effectively halt disease progression are still lacking, and focused efforts are needed to address this public health challenge. Because AD is classically recognized as a disease of memory, studies have mainly focused on investigating memory-associated brain defects. However, compelling evidence has indicated that additional brain regions, not classically linked to memory, are also affected in the course of disease. In this review, we outline the current understanding of key pathophysiological mechanisms in AD and their clinical manifestation. We also highlight how considering the complex nature of AD pathogenesis, and exploring repurposed drug approaches can pave the road toward the development of novel therapeutics for AD.
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影响因子：
3.7
作者：
Blennow K
通讯作者：
Blennow K
影响因子：
8.8
作者：
Broussard JI;Yang K;Levine AT;Tsetsenis T;Jenson D;Cao F;Garcia I;Arenkiel BR;Zhou FM;De Biasi M;Dani JA
通讯作者：
Dani JA
DOI：
10.1016/s0140-6736(20)32205-4
发表时间：
2021-04-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Scheltens P;De Strooper B;Kivipelto M;Holstege H;Chételat G;Teunissen CE;Cummings J;van der Flier WM
通讯作者：
van der Flier WM
影响因子：
82.9
作者：
Baruch, Kuti;Deczkowska, Aleksandra;Schwartz, Michal
通讯作者：
Schwartz, Michal
影响因子：
15.1
作者：
Bjorklund NL;Reese LC;Sadagoparamanujam VM;Ghirardi V;Woltjer RL;Taglialatela G
通讯作者：
Taglialatela G