Association of MTHFR C677T gene polymorphism with metabolic syndrome in a Chinese population: a case-control study
Association of MTHFR C677T gene polymorphism with metabolic syndrome in a Chinese population: a case-control study
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DOI：
10.1177/0300060518768969
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发表时间：
2018-07-01
影响因子：
1.6
通讯作者：
Tang, Shiqi
中科院分区：
文献类型：
--
作者：
Wang, Jin;Xu, Lijuan;Tang, Shiqi
目的 探讨湖北省人群MTHFR C677T基因多态性与代谢综合征（MetS）的相关性。方法对2016年1月至12月武汉大学人民医院651例MetS受试者（MetS组）和727例健康对照者（对照组）进行病例对照研究，采用基因芯片技术检测MTHFR C677T基因型并收集临床资料。 MetS 组的体重指数、腰围、腰臀比、收缩压和舒张压、空腹血糖、空腹胰岛素、甘油三酯、总胆固醇、低密度脂蛋白胆固醇和同型半胱氨酸水平以及胰岛素抵抗的稳态模型评估均高于对照组。 TT 基因型和 T 等位基因携带者的 MetS 风险高于 CC 基因型和 C 等位基因携带者。对于 MetS，TT 基因型会增加血压、空腹血糖水平和甘油三酯水平升高的风险。与CC基因型患者相比，TT基因型MetS患者表现出更严重的腹部肥胖、血脂异常、胰岛素抵抗、血压升高、空腹血糖升高和高同型半胱氨酸血症。结论在该人群中，MTHFR C677T基因多态性可能是MetS的危险因素。
Objective To investigate the association of the MTHFR C677T gene polymorphism with metabolic syndrome (MetS) in people in Hubei Province, China.Methods A case-control study was conducted with 651 subjects with MetS (MetS group) and 727 healthy controls (control group) at Renmin Hospital of Wuhan University between January and December 2016. The MTHFR C677T genotype was detected by the gene chip technique and clinical data were collected.Results Body mass index, waist circumference, the waist-hip-ratio, systolic and diastolic blood pressure, fasting blood glucose, fasting insulin, triglyceride, total cholesterol, low-density lipoprotein-cholesterol, and homocysteine levels, and the homeostasis model assessment of insulin resistance were higher in the MetS group than in controls. The risk of MetS was higher for the TT genotype and T allele carriers than for the CC genotype and C allele carriers. With MetS, the TT genotype increased the risk of elevated blood pressure, fasting glucose levels, and triglyceride levels. Patients with MetS and the TT genotype showed more severe abdominal obesity, dyslipidaemia, insulin resistance, elevated blood pressure, elevated fasting glucose levels, and hyperhomocysteinaemia compared with those with the CC genotype.Conclusions In this population, MTHFR C677T gene polymorphism may be a risk factor for MetS.