β-Dihydroagarofuran-Type Sesquiterpenes from the Seeds of Celastrus monospermus and Their Lifespan-Extending Effects on the Nematode Caenorhabditis elegans
β-Dihydroagarofuran-Type Sesquiterpenes from the Seeds of Celastrus monospermus and Their Lifespan-Extending Effects on the Nematode Caenorhabditis elegans
复制标题
南蛇藤种子中的β-二氢沉香呋喃型倍半萜及其对线虫的延长寿命作用
DOI：
10.1021/acs.jnatprod.6b00648
复制
发表时间：
2016-12-01
影响因子：
5.1
通讯作者：
Zhao, Weimin
中科院分区：
文献类型：
--
作者：
Gao, Lei;Zhang, Rujun;Zhao, Weimin
从单籽南蛇藤（Celastrus monospermus）种子中分离得到17个β-二氢沉香呋喃型倍半萜，其中15个（1-15）为新天然产物。使用标准模型动物线虫秀丽隐杆线虫评价了9个分离株的寿命延长作用。结果表明，所有化合物均能延长C.与空白对照组比较，P < 0.0001。其中，南蛇藤素E（5）延长了C. elegans，具有与雷帕霉素类似的效果，雷帕霉素是一种阳性对照，实验发现其可以延缓酵母、蠕虫、果蝇和小鼠的衰老过程。
Seventeen beta-dihydroagarofuran-type sesquiterpenes were isolated from the seeds of Celastrus monospermus, and, among them, 15 (1-15) were identified as new natural products. Nine isolates were evaluated for their lifespan-extending effect using the standard model animal nematode Caenorhabditis elegans. As a result, all of the tested compounds prolonged the lifespan of C. elegans when compared to the blank control group (p < 0.0001). Among them, celaspermin E (5) extended the average lifespan and maximum lifespan of C. elegans, with effects similar to those of rapamycin, a positive control that has been found experimentally to delay the aging process of yeasts, worms, fruit flies, and mice.