Relationship between Exhaled Hydrogen and Human Neutrophil Function in the Japanese General Population
Relationship between Exhaled Hydrogen and Human Neutrophil Function in the Japanese General Population
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2014-09
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通讯作者：
R. Tanikawa;I. Takahashi;Noriyuki Okubo;Masami Ono;Toshiki Okumura;Goshi Ishibashi;Yosuke Takeishi;M. Nakayama;Tomohiko Yano;Y. Kumasaka;S. Nakaji
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作者：
R. Tanikawa;I. Takahashi;Noriyuki Okubo;Masami Ono;Toshiki Okumura;Goshi Ishibashi;Yosuke Takeishi;M. Nakayama;Tomohiko Yano;Y. Kumasaka;S. Nakaji
我们检查了呼出的氢气量和中性粒细胞ROS产生之间的关系，以研究氢气对正常状态下普通人群中氧化应激的影响，该普通人群包括参加了在日本北方青森县弘前市岩城地区举行的“2007年岩城健康促进项目”的受试者。患有糖尿病（由医生诊断）、恶性肿瘤、免疫疾病或在研究时怀孕、服用抗菌药物、抗癌药物或激素的受试者被排除在研究之外，最终共656例受试者（252例男性和404例女性）入组。调查吸烟习惯、饮酒习惯、运动习惯和HbA 1c。在小于60岁的受试者中，呼出氢浓度与刺激的中性粒细胞中总活性氧产生呈正相关。（p<0.05），但在其他年龄组和女性受试者中未观察到这种趋势。总之，体内氢作为一种抗氧化物质的水平被认为增加了作为对中性粒细胞增加ROS产生的反应，作为对抗氧化应激的机制。广崎医学杂志65：138 - 146，2014
We examined the relationship between the amount of exhaled hydrogen and neutrophil ROS production to investigate the effect of hydrogen on oxidative stress at normal state among the general population comprising subjects who had participated in “The Iwaki Health Promotion Project in 2007”, which was held in the Iwaki area, Hirosaki-city in Aomori prefecture in northern Japan. Subjects with diabetes mellitus (diagnosed by a medical doctor), malignant tumors, immune disorders or those who were pregnant at the time of the study, taking antimicrobial drugs, anticancer medication or hormones were excluded from the study, and a total of 656 subjects (252 males and 404 females) were finally enrolled. Smoking habits, alcohol use, exercise habits and HbA1c were surveyed. A positive correlation was seen between exhaled hydrogen concentration and total reactive oxygen species production in stimulated neutrophils in subjects less than 60 y.o. (p<0.05), but such a trend was not seen in other age groups or in female subjects. In conclusion, levels of body hydrogen as an antioxidative substance were suggested to have increased as a response to increased production of ROS by neutrophils as mechanisms against oxidative stress. Hirosaki Med.J. 65:138―146,2014