Short communication Spectrophotometric determination of alendronate in pharmaceutical formulations via complex formation with Fe(III) ions
Short communication Spectrophotometric determination of alendronate in pharmaceutical formulations via complex formation with Fe(III) ions
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发表时间：
2002
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通讯作者：
J. Kuljanin
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作者：
J. Kuljanin
阿仑膦酸钠，非发色双膦酸盐药物治疗各种骨疾病的重要性，和氯化铁（III）在高氯酸溶液中形成的复合物进行了研究。阿仑膦酸钠与发色络合物中的Fe（III）离子的化学计量比被确定为1：1。条件稳定性常数为log Kave =4.50（SD =0.15），表明Fe（III）-阿仑膦酸盐络合物是中等稳定性的络合物。确定了该反应的最佳条件，并建立了测定阿仑膦酸钠浓度范围为8.1-162.5 gm l-1的分光光度法，检测限为2 gm l-1。该方法可用于阿仑膦酸钠片剂中阿仑膦酸钠的直接测定
The formation of the complex between alendronate, non-chromophoric bisphosphonate drug important for the treatment of a variety of bone diseases, and iron(III) chloride in perchloric acid solution was studied. The stoichiometric ratio of alendronate to Fe(III) ions in the chromophoric complex was determined to be 1:1. The conditional stability constant was log Kave =4.50 (SD =0.15), indicating that the Fe(III)–alendronate complex is a complex of medium stability. The optimum conditions for this reaction were ascertained and a spectrophotometric method was developed for the determination of alendronate in the concentration range 8.1–162.5 gm l − 1 , the detection limit being 2 gm l − 1 . The method was validated for the direct determination of alendronate in tablet