Brain-controlled neuromuscular stimulation to drive neural plasticity and functional recovery.
Brain-controlled neuromuscular stimulation to drive neural plasticity and functional recovery.
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DOI：
10.1016/j.conb.2015.03.007
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发表时间：
2015-08
影响因子：
5.7
通讯作者：
Miller LE
中科院分区：
文献类型：
--
作者：
Ethier C;Gallego JA;Miller LE
越来越多的证据表明，适当的神经肌肉刺激可以诱导神经可塑性，并产生运动障碍的功能恢复。这篇评论讨论了这样一个想法，即协调刺激与患者的自愿努力可能会进一步提高神经康复。细胞培养和行为动物的研究已经描绘了当单个神经元被用作触发器时神经可塑性的潜在规则。然而，更复杂的刺激和更大的网络的规则还不太清楚。我们认为，功能恢复可能会得到优化，如果刺激调制的脑机接口，以配合病人的自愿意图的细节。这种新方法的潜力突出了需要更好地理解这种形式的可塑性背后的复杂规则。
There is mounting evidence that appropriately timed neuromuscular stimulation can induce neural plasticity and generate functional recovery from motor disorders. This review addresses the idea that coordinating stimulation with a patient’s voluntary effort might further enhance neurorehabilitation. Studies in cell cultures and behaving animals have delineated the rules underlying neural plasticity when single neurons are used as triggers. However, the rules governing more complex stimuli and larger networks are less well understood. We argue that functional recovery might be optimized if stimulation were modulated by a brain machine interface, to matched the details of the patient’s voluntary intent. The potential of this novel approach highlights the need for a better understanding of the complex rules underlying this form of plasticity.