Effect of exenatide on gastric emptying and relationship to postprandial glycemia in type 2 diabetes
Effect of exenatide on gastric emptying and relationship to postprandial glycemia in type 2 diabetes
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DOI：
10.1016/j.regpep.2008.07.003
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发表时间：
2008-11-29
影响因子：
--
通讯作者：
Horowitz, Michael
中科院分区：
文献类型：
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作者：
Linnebjerg, Helle;Park, Soomin;Horowitz, Michael
目的：使用闪烁扫描技术评估艾塞那肽对 2 型糖尿病胃排空 (GE) 的影响。方法：17 名 2 型糖尿病受试者参加了一项随机、单盲、3 个周期的研究。交叉研究。在每5天期间，皮下BID施用5或10μg艾塞那肽或安慰剂。继续口服抗糖尿病治疗。在筛选过程中评估心脏自主神经病变的存在。第5天，早上服药后，受试者食用450 kcal的早餐，其中含有Tc-99m标记的鸡蛋和In-m标记的水，并通过闪烁扫描法测量GE。血浆葡萄糖和胰岛素、食欲感知和血浆艾塞那肽也被量化。结果：艾塞那肽减缓了固体和液体膳食成分的 GE [固体（T-50（90% 置信区间 [CI]）；安慰剂，60（50-70）分钟；5 μg 艾塞那肽。111（94-132）分钟；10 μg 艾塞那肽，169（143-201）分钟；均为 P
Objectives: To evaluate the effect of exenatide on gastric emptying (GE) in type 2 diabetes using scintigraphy. Methods: Seventeen subjects with type 2 diabetes participated in a randomized, single-blind, 3-period. crossover study. In each 5-day period, 5 or 10 mu g exenatide or placebo was administered subcutaneously BID. Oral antidiabetic treatments were continued. The presence of cardiac autonomic neuropathy was assessed during screening. On day 5. after the morning dose, subjects consumed a 450-kcal breakfast containing Tc-99m-labeled eggs and In-m-labeled water, and GE was measured by scintigraphy. Plasma glucose and insulin, perceptions of appetite, and plasma exenatide were also quantified. Results: Exenatide slowed GE of both solid and liquid meal components [solid (T-50(90% confidence interval [CI]); placebo, 60(50-70) min; 5 mu g exenatide. 111(94-132) min; 10 mu g exenatide, 169(143-201) min; both P