SPATIAL ABILITY IN ANDROGEN-DEFICIENT MEN
SPATIAL ABILITY IN ANDROGEN-DEFICIENT MEN
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DOI：
10.1056/nejm198205203062003
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发表时间：
1982-01-01
影响因子：
158.5
通讯作者：
CROWLEY, WF
中科院分区：
文献类型：
--
作者：
HIER, DB;CROWLEY, WF
先前的一些证据表明雄激素影响认知能力。为了描述这一缺陷，将19例特发性低促性腺激素性性腺功能减退症男性患者与19例对照男性患者和5例青春期后发生的获得性高促性腺激素性性腺功能减退症男性患者进行了比较。19例特发性性腺功能减退症患者的空间能力明显低于对照组和获得性性腺功能减退症患者（P < 0.05）。患者的空间能力与睾丸体积呈正相关（P < 0.05）。雄激素替代治疗6例患者没有改善他们的空间能力。特发性低促性腺激素性性腺功能减退症男性患者的空间能力受损，获得性低促性腺激素性性腺功能减退症男性患者的空间能力受损，以及外源性雄激素无法纠正特发性低促性腺激素性性腺功能减退症男性患者的空间能力受损，这表明雄激素在青春期前或青春期对男孩的大脑产生永久性的组织影响。
Several lines of previous evidence have suggested that androgens affect cognitive abilities. In an effort to characterize this defect, 19 men with idiopathic hypogonadotropic hypogonadism were compared with 19 control men and with 5 men with acquired hypergonadotropic hypogonadism that had developed after puberty. The 19 patients with idiopathic hypogonadism had markedly impaired spatial ability in comparison to either controls or subjects with acquired hypogonadism (P < 0.05). Moreover, the spatial ability of the patients correlated positively with their testicular voluem (P < 0.05). Androgen-replacement therapy in 6 of the patients did not improve their spatial ability. The impairment in spatial ability in men with the idiopathic form of hypogonadotropic hypogonadism, the lack of such an impairment in men with the acquired form and the failure of exogenous androgens to correct the deficits in the idiopathic form suggest that androgens exert a permanent organizing influence on the brain before or at puberty in boys.