FUTURE APPROACHES TO VACCINE DEVELOPMENT - SINGLE-DOSE VACCINES USING CONTROLLED-RELEASE DELIVERY SYSTEMS
FUTURE APPROACHES TO VACCINE DEVELOPMENT - SINGLE-DOSE VACCINES USING CONTROLLED-RELEASE DELIVERY SYSTEMS
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DOI：
10.1016/0264-410x(93)90241-o
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发表时间：
1993-03-01
期刊：
影响因子：
5.5
通讯作者：
AGUADO, MT
中科院分区：
文献类型：
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作者：
AGUADO, MT
研制单剂疫苗，主要是在儿童时期接种的疫苗，可以有效预防某些疾病，这将是朝着提高免疫覆盖率和预防相应病原体方面取得的一项非常重要的进展。可生物降解的聚合物微球可以在需要增强免疫反应时传递抗原，这可能是实现这一目标的一种可能方法。
The development of single-dose vaccines, mainly those administered during childhood, which would effectively protect against certain diseases, would be a very important advance towards better immunization coverage and protection against the respective pathogens. Biodegradable polymeric microspheres which are 'programmed' to deliver the antigen when a boost of the immune response is required, may be a possible way of achieving this goal.