The PRECIS-2 tool: designing trials that are fit for purpose
The PRECIS-2 tool: designing trials that are fit for purpose
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DOI：
10.1136/bmj.h2147
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发表时间：
2015-05-08
影响因子：
105.7
通讯作者：
Zwarenstein, Merrick
中科院分区：
文献类型：
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作者：
Loudon, Kirsty;Treweek, Shaun;Zwarenstein, Merrick
PRECIS是一种帮助试验者做出与试验预期目的一致的设计决策的工具。本文提供了如何使用改进的，经过验证的版本PRECIS-2的指导，该版本是在80多名国际试验人员，临床医生和政策制定者的帮助下开发的。PRECIS-2保留了最初的简单轮格式，有9个领域-资格标准，招募，设置，组织，灵活性（交付），灵活性（遵守），随访，主要结果和主要分析-得分从1（非常解释性）到5（非常务实），以促进领域讨论和共识。希望PRECIS-2在支持设计决策与试验结果的预期使用方式的明确匹配方面具有价值
PRECIS is a tool to help trialists make design decisions consistent with the intended purpose of their trial. This paper gives guidance on how to use an improved, validated version, PRECIS-2, which has been developed with the help of over 80 international trialists, clinicians, and policymakers. Keeping the original simple wheel format, PRECIS-2 has nine domains-eligibility criteria, recruitment, setting, organisation, flexibility (delivery), flexibility (adherence), follow-up, primary outcome, and primary analysis-scored from 1 (very explanatory) to 5 (very pragmatic) to facilitate domain discussion and consensus. It is hoped PRECIS-2 will be valuable in supporting the explicit matching of design decisions to how the trial results are intended to be used