Fine-needle aspiration cytology of metastatic nasopharyngeal carcinoma in cervical lymph nodes: Comparison with metastatic squamous-cell carcinoma, and Hodgkin's and non-Hodgkin's lymphoma
Fine-needle aspiration cytology of metastatic nasopharyngeal carcinoma in cervical lymph nodes: Comparison with metastatic squamous-cell carcinoma, and Hodgkin's and non-Hodgkin's lymphoma
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DOI：
10.1002/dc.10218
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发表时间：
2003-01-01
影响因子：
1.3
通讯作者：
El Hag, IA
中科院分区：
文献类型：
--
作者：
Kollur, SM;El Hag, IA
本研究的目的是比较鼻咽癌（NPC）与非鼻咽来源的鳞状细胞癌（SCC）、霍奇金淋巴瘤（HL）和非霍奇金淋巴瘤（NHL）颈部淋巴结的细胞形态学特征。本研究的目的是找到简单的细胞学标准，使用常规染色，可以帮助区分这些实体。本研究纳入了我们文件中可用的颈淋巴结转移性NPC、SCC、HL和NHL的所有细针穿刺（FNA）涂片。所有病例均以结节病为首发临床表现，病变均为非角化型。转移性NPC、SCC、HL和NHL的细胞形态学特征已被描述。转移性NPC和HL有相似的反应性淋巴背景，嗜酸性粒细胞，浆细胞，有时上皮样细胞肉芽肿。NPC的奇异细胞与HL的Reed-Sternberg细胞有一定的相似性。然而，后者可以从大体积的、淡灰色的空泡状细胞质和泡状核以及边界清晰的突出的大核的基础上与前者区分开来。NPC中的肿瘤细胞与背景中的正常淋巴样细胞形成明显的聚集，这与NHL中单调分散的细胞群不同。此外，奇异的细胞，突出的核仁，以及浆细胞，嗜酸性粒细胞和肉芽肿的存在并不是NHL的常见特征。转移性鳞状细胞癌的涂片显示角化恶性细胞在所有情况下，而嗜酸性粒细胞和浆细胞的背景下缺席。在所有NPC病例中，浆细胞与肿瘤细胞密切相关。总之，转移性鼻咽癌可以从转移性鳞状细胞癌的非鼻咽起源，HL和NHL的基础上简单的核和细胞质的恶性细胞和他们的背景的特征进行区分。浆细胞与肿瘤细胞簇的混合是鼻咽起源的良好指标。另一方面，在存在角化恶性细胞的情况下，鼻咽起源不太可能。(C)2002 Wiley-Liss，Inc.
Our objective was to study the cytomorphological features of metastatic nasopharyngeal carcinoma (NPC) as compared to squamous-cell carcinoma (SCC) of nonnasopharyngeal origin, Hodgkin's lymphoma (HL), and non-Hodgkin's (NHL) lymphoma in the neck lymph nodes. The aim of this study was to find simple cytological criteria using routine stains that can help in differentiating between these entities. All fine-needle aspiration (FNA) smears of metastatic NPC, SCC, HL, and NHL from neck nodes available in our files were included in this study. Nodal disease was the first clinical manifestation in all cases of NPC, and all the lesions were of the nonkeratinizing type. The cytomorphological features of metastatic NPC, SCC, HL, and NHL have been described. Metastatic NPC and HL had a similar reactive lymphoid background, with eosinophils, plasma cells, and sometimes epithelioid-cell granulomas. The bizarre cells of NPC showed some resemblance to Reed-Sternberg cells of HL. However, the latter can be distinguished from the former oil the basis of bulky, pale gray, vacuolated cytoplasm and vesicular nuclei with sharply demarcated prominent macronucleoli. In NPC, the neoplastic cells form distinct aggregates contrasting with the normal lymphoid cells in the background, which was different from the monotonous dispersed population of cells in NHL. Moreover, bizarre cells, prominent nucleoli, and the presence of plasma cells, eosinophils, and granulomas were not common features of NHL. The smears of metastatic SCC revealed keratinized malignant cells in all cases, while eosinophils and plasma cells were absent in the background. Plasma cells were seen intimately related to tumor cells in all cases of NPC. In conclusion, metastatic NPC can be differentiated from metastatic SCC of nonnasopharyngeal origin, HL, and NHL on the basis of simple nuclear and cytoplasmic features of malignant cells and their background. The presence of plasma cells intermingling with tumor-cell clusters is a good indicator of nasopharyngeal origin. On the other hand, a nasopharyngeal origin is unlikely in the presence of keratinized malignant cells. (C) 2002 Wiley-Liss, Inc.