Targeting cardiovascular disease with novel SIRT1 pathways.
Targeting cardiovascular disease with novel SIRT1 pathways.
复制标题
DOI：
10.2217/fca.11.76
复制
发表时间：
2012-01
影响因子：
1.7
通讯作者：
Maiese K
中科院分区：
文献类型：
--
作者：
Chong ZZ;Wang S;Shang YC;Maiese K
sirtuin（酵母S.cerevisiae的沉默信息调节2的哺乳动物同源物）1（SIRT 1）是NAD依赖性组蛋白脱乙酰酶，已成为响应氧化应激的关键调节剂。通过拮抗氧化应激诱导的细胞损伤和通过维持体内代谢稳态，SIRT 1可以阻断血管系统损伤。SIRT 1靶向多种细胞蛋白，如过氧化物酶体增殖物激活受体-γ（PPAR-γ）及其共激活因子-1 α（PGC-1α）、叉头转录因子、AMP激活蛋白激酶（AMPK）、核因子-κB（NF-κB）和蛋白酪氨酸磷酸酶（PTP），以调节多种疾病的复杂细胞通路。在心血管系统中，SIRT 1的激活不仅可以在细胞水平上保护免受氧化应激，而且还可以在全身水平上提高生存率，以限制冠心病和脑血管疾病。SIRT 1及其新途径的未来知识可以为心血管疾病的治疗开辟新的方向，并提供限制几种相关疾病残疾的潜力。
The sirtuin (the mammalian homolog of silent information regulation 2 of yeast S.cerevisiae) 1 (SIRT1), a NAD-dependent histone deacetylase, has emerged as a critical regulator in response to oxidative stress. Through antagonism of oxidative stress-induced cell injury and through the maintenance of metabolic homeostasis in the body, SIRT1 can block vascular system injury. SIRT1 targets multiple cellular proteins, such as peroxisome proliferators-activated receptor-γ (PPAR-γ) and its coactivator-1α (PGC-1α), forkhead transcriptional factors, AMP-activated protein kinase (AMPK), nuclear factor-κB (NF-κB), and protein tyrosine phosphatase (PTP) to modulate intricate cellular pathways of multiple diseases. In the cardiovascular system, activation of SIRT1 can not only protect at the cellular level against oxidative stress, but also offer increased survival at the systemic level to limit coronary heart disease and cerebrovascular disease. Future knowledge of SIRT1 and its novel pathways can open new directions for the treatment of cardiovascular disease as well as offer the potential to limit disability from several related disorders.