Olfactory bulbectomy in mice induces alterations in exploratory behavior
Olfactory bulbectomy in mice induces alterations in exploratory behavior
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DOI：
10.1016/j.neulet.2004.10.040
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发表时间：
2005-02
影响因子：
2.5
通讯作者：
Maha Zueger;A. Urani;S. Chourbaji;C. Zacher;M. Roche;A. Harkin;P. Gass
中科院分区：
文献类型：
--
作者：
Maha Zueger;A. Urani;S. Chourbaji;C. Zacher;M. Roche;A. Harkin;P. Gass
嗅球切除综合征被认为是一种精神焦虑性抑郁的啮齿动物模型。虽然该模型已在大鼠中得到广泛表征，但在小鼠中进行的研究较少。因此，本研究旨在扩展OBX诱导的小鼠行为综合征的表征，使用开放领域，新物体探索，新笼子和T-迷宫学习等测试。OBX小鼠在明亮照明的开放场地中表现出活动过度，并且在新的饲养笼中以及在T-迷宫中也表现出活动过度。此外，OBX小鼠在新物体测试和T-迷宫中表现出增加的探索行为。这里描述的关于运动和探索的复杂改变是稳健的，并且可以通过相对简单的测试程序来实现。鼠OBX模型的扩展行为表征可能特别有助于测试转基因小鼠是否存在抑郁样行为的需求增加。
The olfactory bulbectomy syndrome is thought to represent a rodent model for psychomotor agitated depression. While this model has been extensively characterized in rats, fewer studies have been conducted with mice. Therefore, the present study aimed at extending the characterization of the OBX-induced behavioral syndrome in mice, using tests like open field, novel object exploration, novel cage and T-maze learning. OBX mice exhibited hyperactivity in a brightly illuminated open field, and also in a novel home cage as well as in the T-maze. Furthermore, OBX mice demonstrated increased exploratory behavior in the novel object test and in the T-maze. The complex alterations described here with respect to locomotion and exploration are robust and can be achieved by relatively simple test procedures. The extended behavioral characterization of the murine OBX model may contribute in particular to the increasing need to test transgenic mice for the presence of depression-like behaviors.