Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light
Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light
复制标题
工程溶酶体靶向 BODIPY 纳米粒子用于近红外光下的光声成像和光动力治疗。
DOI：
10.1021/acsami.6b02721
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发表时间：
2016-05-18
影响因子：
9.5
通讯作者：
Huang, Wei
中科院分区：
文献类型：
--
作者：
Hu, Wenbo;Ma, Hengheng;Huang, Wei
开发结合光声成像（PAI）和光动力治疗（PDT）功能的溶酶体靶向有机纳米颗粒用于个性化医疗是非常需要的，但也具有挑战性。本研究首次设计了溶酶体靶向BODIPY纳米颗粒，将近红外（NIR）吸收的BODIPY染料包埋在两亲性的DSPE-mPEG5000中，在近红外光下对癌细胞进行高效的溶酶体PAI和酸激活的PDT。
Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against cancer cells under NIR light.