Circulating vascular endothelial growth factor levels in patients with obstructive sleep apnea
Circulating vascular endothelial growth factor levels in patients with obstructive sleep apnea
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DOI：
10.1093/sleep/25.1.59
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发表时间：
2002-02-01
期刊：
影响因子：
5.6
通讯作者：
Jones, KL
中科院分区：
文献类型：
--
作者：
Gozal, D;Lipton, AJ;Jones, KL
研究目的：阻塞性睡眠呼吸暂停（OSA）与睡眠期间的间歇性缺氧有关。血管内皮生长因子（VEGF）在循环中具有可检测的水平，并且其表达受氧张力高度调节。因此，我们假设血清VEGF水平将升高，在患者与OSA。设计：血液样本收集在随机时间从白天从纤维蛋白原成人和41名儿童谁是临床怀疑存在OSA，并进行了夜间多导睡眠图。设置：大学医院睡眠实验室。参与者：N/A干预：N/A测量和结果：对于儿童和成人，多导睡眠图证实的OSA患者的血清VEGF水平显著升高，（成人和儿童分别为AHI>15和AI>5）与轻度或无疾病的患者相比（成人和儿童使用p30和呼吸暂停指数>5作为疾病标准，结论：我们得出的结论是，阻塞性睡眠呼吸暂停综合症患者循环中的血管内皮生长因子水平经常升高，并且可能在调节组织氧气输送方面发挥作用。
Study Objectives: Obstructive sleep apnea (OSA) is associated with intermittent hypoxia during sleep. Vascular endothelial growth factor (VEGF) has detectable levels in the circulation and its expression is highly regulated by oxygen tension. We therefore hypothesized that serum VEGF levels will be elevated in patients with OSA.Design: Blood samples were collected at random times during the day from fib adults and 41 children who were clinically suspected for the presence of OSA, and who underwent overnight polysomnography.Setting: University hospital sleep laboratory.Participants: N/AInterventions: N/AMeasurements and Results: For both children and adults, serum VEGF levels were significantly higher in polysomnographically confirmed OSA (AHI>15 and AI>5 in adults and children respectively) when compared to those with mild or no disease (p30 and an apnea index >5 were used as disease criteria in adults and children, respectively.Conclusions: We conclude that circulating VEGF levels are frequently elevated in OSA patients, and may play a role in the regulation of tissue oxygen delivery.