Four years incidence of diabetic retinopathy and effective factors on its progression in type II diabetes
Four years incidence of diabetic retinopathy and effective factors on its progression in type II diabetes
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DOI：
10.1177/112067210801800412
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发表时间：
2008-07-01
影响因子：
1.7
通讯作者：
Afkhami-Ardekani, M.
中科院分区：
文献类型：
--
作者：
Manaviat, M. R.;Rashidi, M.;Afkhami-Ardekani, M.
目的。探讨2型糖尿病患者糖尿病视网膜病变4年发病情况及影响其进展的影响因素。方法。在转诊至 Yazd 糖尿病研究中心的糖尿病患者中，选择了 120 名无糖尿病视网膜病变的 II 型糖尿病患者。完成眼科检查后，测量空腹血糖（FBS）、餐后血糖、甘油三酯和胆固醇，并记录身高、体重和血压（BP）。然后患者每年进行一次眼科检查，为期 4 年。 结果。糖尿病视网膜病变的四年累计发病率为 47.5%（95% CI：38.6-56.4）。 43 名患者（35.8%）的视网膜病变为轻度非增殖性糖尿病视网膜病变（NPDR），10 名患者（8.3%）为中度 NPDR，3 名患者（2.5%）为重度 NPDR，只有 1 名患者患有增殖性糖尿病视网膜病变。糖尿病视网膜病变的发病率第一年为5.8%，第二年为20.3%，第三年为24.4%，第四年为7.4%。糖尿病病程、FBS和收缩压与糖尿病视网膜病变的分级有统计学显着相关性。然而，年龄、性别、体重指数、甘油三酯、胆固醇、治疗方法、吸烟和舒张压与糖尿病视网膜病变的分级之间没有显着相关性。结论。这些数据提供了 2 型糖尿病患者 4 年累积的糖尿病视网膜病变发病率。本研究表明，糖尿病病程、高血糖和收缩压似乎是与 2 型糖尿病患者发生任何级别的视网膜病变相关的主要因素。 （欧洲眼科杂志 2008 年；18：572-7）
PURPOSE. To study the 4 years incidence of diabetic retinopathy in patients with type II diabetes and effective factors on its progression.METHODS. Among diabetic patients referred to Yazd Diabetes Research Center, 120 patients with type II diabetes without diabetic retinopathy were selected. After complete ophthalmic examination, fasting blood sugar (FBS), postprandial blood sugar, triglyceride, and cholesterol were measured and height, weight, and blood pressure (BP) were recorded. Then patients were followed with eye examination yearly for 4 years.RESULTS. Four-year cumulative incidence of diabetic retinopathy was 47.5% (95% CI: 38.6-56.4). The retinopathy was mild nonproliferative diabetic retinopathy (NPDR) in 43 (35.8%) whereas 10 (8.3%) patients had moderate NPDR, 3 (2.5%) patients had severe NPDR, and only one patient had proliferative diabetic retinopathy. The incidence of diabetic retinopathy was 5.8% in first year, 20.3% in the second year, 24.4% in the third year, and 7.4% in the fourth year. Duration of diabetes, FBS, and systolic BP had statistically significant relation with grades of diabetic retinopathy. However, there was no significant association between age, sex, body mass index, triglyceride, cholesterol, method of treatment, smoking, and diastolic BP with grades of diabetic retinopathy.CONCLUSIONS. These data provide 4-year cumulative incidence of diabetic retinopathy in defined type 2 diabetic patients. The present study shows that duration of diabetes, hyperglycemia, and systolic BP appear to be the major factors associated with the development of any level of retinopathy in type 2 diabetic patients. (Eur J Ophthalmol 2008; 18: 572-7)