Seeking the neural substrates of visual working memory storage
Seeking the neural substrates of visual working memory storage
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DOI：
10.1016/s0010-9452(08)70871-2
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发表时间：
2003-09-01
期刊：
影响因子：
3.6
通讯作者：
D'Esposito, M
中科院分区：
文献类型：
--
作者：
Postle, BR;Druzgal, TJ;D'Esposito, M
人们普遍认为，前额叶皮层（PFC）是猴子和人类工作记忆存储的关键部位。然而，最近对人类病变文献的回顾和最近的神经影像学结果，对这一观点提出了挑战。为了测试这些备选方案，我们使用了事件相关的功能磁共振成像（fMRI）来追踪目标面孔工作记忆表征的保留情况，这些工作记忆表征跨越了四个刺激呈现之间的三个延迟期。在所有受试者中，只有后梭状回在所有延迟期表现出可靠的目标特异性活动保留。我们的研究结果表明，额叶皮层的任何部分，包括PFC，都不能在分散注意力的延迟期可靠地存储人脸的助记表征。相反，面孔的工作记忆存储是由后皮层的特定领域网络介导的。
It is widely assumed that the prefrontal cortex (PFC) is a critical site of working memory storage in monkeys and humans. Recent reviews of the human lesion literature and recent neuroimaging results, however, challenge this view. To test these alternatives, we used event-related fMRI to trace the retention of working memory representation of target faces across three delay periods that were interposed between the presentation of each of four stimuli. Across subjects, only posterior fusiform gyrus demonstrated reliable retention of target-specific activity across all delay periods. Our results suggest that no part of frontal cortex, including PFC, stores mnemonic representation of faces reliably across distracted delay periods. Rather, working memory storage of faces is mediated by a domain-specific network in posterior cortex.