THE FATE OF MITOCHONDRIA DURING AGING IN TETRAHYMENA PYRIFORMIS.
THE FATE OF MITOCHONDRIA DURING AGING IN TETRAHYMENA PYRIFORMIS.
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DOI：
10.1083/jcb.20.1.113
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发表时间：
1964-01
期刊：
影响因子：
--
通讯作者：
BAK IJ
中科院分区：
文献类型：
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作者：
ELLIOTT AM;BAK IJ
在梨形四膜虫的生长周期中，线粒体经历了位置、数量和结构的变化。对数生长期的纤毛虫具有沿着质膜排列的细长线粒体，并与动丝和动丝紧密相连。此时线粒体似乎沿着长轴分裂，产生两种或更多种产物。在整个生长阶段，线粒体分裂与胞质分裂保持同步，因此线粒体数量基本上保持在最低水平。当纤毛虫进入稳定生长期时，线粒体数量增加，形状变为椭圆形至球形，并且一些线粒体迁移到细胞质中。此时出现各种形态的线粒体内团块。一些位于细胞质中的线粒体被并入液泡中。在这些空泡中，或者出现单个线粒体，或者沿着其他细胞质结构出现几个线粒体。在稳定生长期后期，所含线粒体较致密，小管比正常情况下更紧凑。在单个大液泡中观察到线粒体解体的各个阶段。细胞化学试验显示存在酸性磷酸酶，表明液泡内容物发生水解。在生长稳定期的中期和后期，脂滴的数量增加。这些事件被解释为与T的正常衰老过程有关。梨形。
During the growth cycle of Tetrahymena pyriformis the mitochondria undergo changes in position, number, and structure. Ciliates in the logarithmic growth phase possess elongated mitochondria which are aligned along the plasma membrane and are closely associated with the kinetosomes and kinetodesmata. Mitochondria appear to divide across the long axis at this time, resulting in two or more products. Throughout this phase of growth mitochondrial divisions keep pace with cytokinesis so that the population of mitochondria remains at essentially the minimal level. As the ciliates enter the stationary growth phase the mitochondria increase in number, become oval to spherical in shape, and some migrate into the cytoplasm. Intramitochondrial masses of various configurations appear at this time. Some of the mitochondria lying in the cytoplasm become incorporated into vacuoles. Within these vacuoles either a single mitochondrion appears or several mitochondria may be seen along with other cytoplasmic structures. Later in the stationary growth phase the contained mitochondria are dense and the tubules are more compact than normal. Various stages in disorganization of the mitochondria are observed in a single large vacuole. Cytochemical tests reveal the presence of acid phosphatase, suggesting that hydrolysis of the vacuolar contents occurs. Lipid droplets increase in number during the middle and late stationary phase of growth. These events are interpreted as being associated with the normal process of aging in T. pyriformis.