MICRO-VASCULAR RAREFACTION IN SPONTANEOUSLY HYPERTENSIVE RAT CREMASTER MUSCLE
MICRO-VASCULAR RAREFACTION IN SPONTANEOUSLY HYPERTENSIVE RAT CREMASTER MUSCLE
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DOI：
10.1152/ajpheart.1981.241.3.h306
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发表时间：
1981-01-01
影响因子：
--
通讯作者：
DOWELL, RF
中科院分区：
文献类型：
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作者：
CHEN, IIH;PREWITT, RL;DOWELL, RF
应用定量体视学方法研究了自发性高血压大鼠（SHR）和Wistar-Kyoto大鼠（WKY）的神经和局部血管效应对血管长度和单位体积表面积的影响。14只SHR和14只WKY（70-130 g）用氯醛糖-氨基甲酸乙酯麻醉，暴露提睾肌作显微镜观察。进入肌肉的大微动脉称为第一级微动脉，连续的分支称为第二级、第三级和第四级微动脉。在3个连续状态下收集数据：神经支配、去神经支配和用硝普钠舒张血管。单位体积的第三和第四级微动脉和毛细血管长度在SHR的所有3种状态下均小于WKY。SHR的单位体积血管表面积也减少。去神经支配和硝普钠（Nipride）导致SHR的血管长度和表面积比WKY增加更大的百分比。在SHR提睾肌中，解剖学上存在较少的末端小动脉和毛细血管，并且在静息条件下，它们中的更大百分比但相似的绝对数量关闭流动。
Neural and local vascular effects on vessel length and surface area per unit volume were studied in spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) by quantitative stereology. Fourteen SHR and 14 WKY (70-130 g) were anesthetized with chloralose-urethane and the cremaster muscle was exposed for microscopic observation. The large arterioles entering the muscle were termed the 1st order, and consecutive branches were termed 2nd-, 3rd and 4th-order arterioles. Data were collected in 3 consecutive states: innervated, denervated and vasodilated with nitroprusside. The 3rd- and 4th-order arteriole and capillary lengths per unit volume in the SHR were less than those of the WKY in all 3 states. The vessel surface area per unit volume was also reduced in the SHR. Denervation and sodium nitroprusside (Nipride) resulted in larger percent increases in vessel length and surface area in the SHR than in the WKY. In the SHR cremaster muscle there are fewer terminal arterioles and capillaries anatomically present, and, under resting conditions, a greater percentage but similar absolute number of them are closed to flow.