Familial Benign Chronic Pemphigus: Induction of Lesions by Candida albicans
Familial Benign Chronic Pemphigus: Induction of Lesions by Candida albicans
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家族性良性慢性天疱疮：白色念珠菌诱发病变
DOI：
10.1001/archderm.1967.01610030032005
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发表时间：
1967
影响因子：
--
通讯作者：
D. T. Omieczynski
中科院分区：
文献类型：
--
作者：
R. Burns;W. Reed;F. Swatek;D. T. Omieczynski
本文报告三例家族性良性慢性天疱疮（FBCP），均在典型的棘层松解性皮损上发现白色念珠菌。在温暖、潮湿的地区，病灶持续存在，而在局部应用类固醇和抗生素治疗下，其他病灶消失，这导致人们猜测真菌可能不仅仅是巧合。为了测试培养的白色念珠菌产生FBCP典型病变的能力，将其应用于所有患者先前未累及的皮肤，并且一致成功。还获得了组织学确认。添加一种能够抑制白色念珠菌的药物制霉菌素（制霉菌素），减少了但不能完全消除新病变的出现。
Three cases of familial benign chronic pemphigus (FBCP) are presented, all of which proved to have Candida albicans superimposed on typical acantholytic lesions. The persistence of lesions in warm, moist regions and the clearing of others under therapy with local application of steroid and antibiotics, led to speculation that the fungi might have been more than a coincidental finding. To test the ability of cultured C albicans to produce typical lesions of FBCP, it was applied to previously uninvolved skin of all patients, and was uniformly successful. Histopathological confirmation was also obtained. The addition of a drug capable of inhibiting C albicans , nystatin (Mycostatin), decreased but did not completely eliminate the appearance of new lesions.