Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease
Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease
复制标题
DOI：
10.1053/j.gastro.2006.03.019
复制
发表时间：
2006-06-01
期刊：
影响因子：
29.4
通讯作者：
Blair, Steven N.
中科院分区：
文献类型：
--
作者：
Church, Timothy S.;Kuk, Jennifer L.;Blair, Steven N.
背景和目标：有必要进行更多的工作来检查身体活动和/或体重控制作为脂肪肝疾病治疗中的预防和/或治疗选择的潜力。本研究的目的是检查心肺功能、体重指数（BMI）和腰围与非酒精性脂肪性肝病（NAFLD）标志物之间的关系。方法：参与者包括218名年龄在33-73岁的健康、不吸烟、不酗酒的男性。通过最大跑台试验评估呼吸适应性。使用计算机断层扫描测量肝脏和脾脏密度。我们将NAFLD的存在定义为满足以下3个条件：（1）肝脏与脾脏的密度为1.0或更小，（2）血清丙氨酸转氨酶水平大于30 U/L，和（3）血清天冬氨酸转氨酶/丙氨酸转氨酶水平小于：1.0。结果：24名（11%）参与者符合NAFLD定义。健康类别与NAFLD患病率呈负相关，BMI类别（和腰围类别）与NAFLD患病率呈正相关（趋势P
Background & Aims: There is a need for more work examining the potential of physical activity and/or weight control as a preventive and/or therapeutic option in the treatment of fatty liver diseases. The purpose of this study was to examine the association between cardiorespiratory fitness, body mass index (BMI), and waist circumference with markers of nonalcoholic fatty liver disease (NAFLD). Methods: Participants consisted of 218 apparently healthy nonsmoking, nonalcoholic men aged 33-73 years. Cardiorespiratory fitness was assessed by a maximal treadmill test. Liver and spleen density were measured using a computed tomography scan. We defined the presence of NAFLD as the following 3 conditions being met: (1) liver to spleen density of 1.0 or less, (2) serum alanine transaminase level greater than 30 U/L, and (3) serum aspartate transaminase/alanine transaminase level less than :1.0. Results: Twenty-four (11%) of the participants met the NAFLD definition. There was an inverse association between fitness categories, and a positive association for BMI categories (and waist circumference categories) with the prevalence of NAFLD (P for trend