Iridium-Catalyzed Allylic Fluorination of Trichloroacetimidates
Iridium-Catalyzed Allylic Fluorination of Trichloroacetimidates
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DOI：
10.1021/ja2087213
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发表时间：
2011-12-07
影响因子：
15
通讯作者：
Nguyen, Hien M.
中科院分区：
文献类型：
--
作者：
Topczewski, Joseph J.;Tewson, Timothy J.;Nguyen, Hien M.
研究了三氯乙酰亚胺酯与铱催化剂联用的快速烯丙基取代法。该反应在室温下在环境空气中进行，并且依赖于Et 3 N中心点3 HF试剂以提供具有完全区域选择性的支链烯丙基氟化物。这种高产率的反应可以在多克规模上进行，并显示出相当大的官能团耐受性。使用[F-18]KF。Kryptofix允许F-18（-）在10 mm中掺入。
A rapid allylic fluorination method utilizing trichloroacetimidates in conjunction with an iridium catalyst has been developed. The reaction is conducted at room temperature under ambient air and relies on Et3N center dot 3HF reagent to provide branched allylic fluorides with complete regioselectivity. This high-yielding reaction can be conducted on a multigram scale and shows considerable functional group tolerance. The use of [F-18]KF. Kryptofix allowed F-18(-) incorporation in 10 mm.