Mechanical properties of the bioabsorbable polyglycolic acid-collagen nerve guide tube
Mechanical properties of the bioabsorbable polyglycolic acid-collagen nerve guide tube
复制标题
DOI：
10.1002/pen.20600
复制
发表时间：
2006-10
影响因子：
3.2
通讯作者：
Satoshi Tanaka;T. Takigawa;S. Ichihara;Tatsuo Nakamura
中科院分区：
文献类型：
--
作者：
Satoshi Tanaka;T. Takigawa;S. Ichihara;Tatsuo Nakamura
由聚乙醇酸（PGA）制成的生物可吸收神经管涂有胶原蛋白，现在被广泛用于遭受神经损伤的患者。神经管的主要功能是在体内维持神经再生的空间，以防止周围组织的快速入侵，直到新的神经组织已经恢复。然而，尚未对生物可吸收神经管进行精确的机械测试。因此，本研究的目的是评价PGA-胶原蛋白管的机械性能，并分析它们能够维持用于恢复神经的导管的通畅性的程度。在本实验中使用直径为3和4 mm的神经管。这些管由圆柱形编织的PGA纤维制成，这些纤维已经被给予5、10或27层胶原蛋白涂层，其最终在140°C下脱氢热交联24小时。进行了体外和体内试验。对于体外测试，将神经管样品浸入37°C的盐水中长达8周。对于体内试验，将样品皮下植入家兔体内，并在植入后观察长达16周。借助于拉伸试验机测量每个样品在压缩应力期间的阻力。胶原涂层增强了管的机械性能，特别是在浸泡后的前2周。用胶原包被27次的管（27 T管）比5 T或10 T管强180%。最初的机械参数，如管刚度，减少一半所需的时间为14天或更长。在体内的管的机械强度的降低发生得比在体外更快。Polym.工程索引，46：1461-1467，2006.© 2006年塑料工程师协会
Bioabsorbable nerve tubes made from polyglycolic acid (PGA) coated with collagen are now used widely for patients who have suffered nerve injury. The main function of nerve tubes is to maintain a space for nerve regeneration in the body against rapid invasion by the surrounding tissue until the new nerve tissue has recovered. However, no precise mechanical testing has ever been carried out on bioabsorbable nerve tubes. The aim of this study was therefore to evaluate the mechanical properties of PGA– collagen tubes and to analyze the degree to which they are able to maintain the patency of the conduit for the recovering nerve. Nerve tubes with diameters of 3 and 4 mm were used in this experiment. The tubes were made from cylindrically woven PGA fibers that had been given 5, 10, or 27 coats of collagen, which was finally crosslinked dehydrothermally at 140°C for 24 h. Both in vitro and in vivo tests were carried out. For in vitro testing, the nerve tube samples were immersed in saline at 37°C for up to 8 weeks. For in vivo testing, samples were implanted subcutaneously into rabbits and observed for up to 16 weeks after implantation. Resistance during compression stress was measured for each sample with the aid of a tensile tester. The collagen coating enhanced the mechanical properties of the tubes, particularly in the first 2 weeks following immersion. The tubes coated with collagen 27 times (27T tubes) were 180% stronger than either the 5T or the 10T tubes. The time taken for the initial mechanical parameters, such as tube rigidity, to be reduced by half was 14 days or more. The reduction in the mechanical strength of the tubes in vivo occurred more rapidly than in vitro. POLYM. ENG. SCI., 46: 1461–1467, 2006. © 2006 Society of Plastics Engineers