Functional magnetic resonance spectroscopy in patients with schizophrenia and bipolar affective disorder: Glutamate dynamics in the anterior cingulate cortex during a working memory task
Functional magnetic resonance spectroscopy in patients with schizophrenia and bipolar affective disorder: Glutamate dynamics in the anterior cingulate cortex during a working memory task
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DOI：
10.1016/j.euroneuro.2018.12.005
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发表时间：
2019-12-01
影响因子：
5.6
通讯作者：
Stone, James M.
中科院分区：
文献类型：
--
作者：
Jelen, Luke A.;King, Sinead;Stone, James M.
谷氨酸系统与精神分裂症和情绪障碍的病理生理学有关。使用功能磁共振波谱 (H-1-fMRS)，可以动态监测激活的大脑区域中的谷氨酸，并且可以比标准磁共振波谱更准确地估计谷氨酸能神经传递。 14 名精神分裂症患者、15 名双相情感障碍 II (BPII) 患者和 14 名健康志愿者在 H-1-fMRS 采集期间以 48 秒的块设计接受了 15 分钟的 N-back 任务。对每个块的第一、第二和第三 16s 组 8 个光谱的数据进行分析，以测量平均 0-back 和 2-back 条件下的谷氨酸和 Glx（谷氨酸 + 谷氨酰胺）水平，并缩放至总肌酸 (TCr)。 6 x 3 重复测量方差分析 (rmANOVA) 证明时间对 Glx/TCr 具有显着的主效应 (P = 0.022)。仅在健康对照组中，0-back 的最终光谱与 2-back 条件的第一个光谱之间的 Glu/TCr (P = 0.004) 和 Glx/TCr (P < 0.001) 显着增加。 2 x 2 rMANOVA 显示，在 0-back 条件下，Glx/TCr 的组间相互作用存在显着时间（P = 0.019），健康对照组的水平降低，精神分裂症组的水平升高。虽然健康志愿者在不同任务条件下谷氨酸能测量值显着增加，但精神分裂症和 BPII 患者缺乏这种反应可能反映了谷氨酸能神经传递的缺陷。在相对较低的执行负荷期间，异常增加，没有与任务难度增加的健康志愿者相同的动态调节，进一步表明精神分裂症中谷氨酸能神经传递的潜在异常。 (c) 2018 Elsevier B.V. 和 ECNP。版权所有。
The glutamate system is implicated in the pathophysiology of schizophrenia and mood disorders. Using functional magnetic resonance spectroscopy (H-1-fMRS), it is possible to monitor glutamate dynamically in activated brain areas and may give a closer estimate of glutamatergic neurotransmission than standard magnetic resonance spectroscopy. 14 patients with schizophrenia, 15 patients with bipolar disorder II (BPII) and 14 healthy volunteers underwent a 15 min N-back task in a 48s block design during H-1-fMRS acquisition. Data from the first, second and third 16s group of 8 spectra for each block were analysed to measure levels of glutamate and Glx (glutamate + glutamine), scaled to total creatine (TCr), across averaged 0-back and 2-back conditions. A 6 x 3 repeated-measures analysis of variance (rmANOVA) demonstrated a significant main effect of time for Glx/TCr (P = 0.022). There was a significant increase in Glu/TCr (P = 0.004) and Glx/TCr (P < 0.001) between the final spectra of the 0-back and first spectra of the 2-back condition in the healthy control group only. 2 x 2 rmANOVA revealed a significant time by group interaction for Glx/TCr (P = 0.019) across the 0-back condition, with levels reducing in healthy controls and increasing in the schizophrenia group. While healthy volunteers showed significant increases in glutamatergic measures between task conditions, the lack of such a response in patients with schizophrenia and BPII may reflect deficits in glutamatergic neurotransmission. Abnormal increases during periods of relatively low executive load, with-out the same dynamic modulation as healthy volunteers with increasing task difficulty, further suggests underlying abnormalities of glutamatergic neurotransmission in schizophrenia. (c) 2018 Elsevier B.V. and ECNP. All rights reserved.