A common oxytocin receptor gene (OXTR) polymorphism modulates intranasal oxytocin effects on the neural response to social cooperation in humans.
A common oxytocin receptor gene (OXTR) polymorphism modulates intranasal oxytocin effects on the neural response to social cooperation in humans.
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DOI：
10.1111/gbb.12234
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发表时间：
2015-09
期刊：
影响因子：
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通讯作者：
Rilling JK
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文献类型：
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作者：
Feng C;Lori A;Waldman ID;Binder EB;Haroon E;Rilling JK
鼻腔内催产素(OT)可以调节人类的社会情绪功能和相关的大脑活动。因此，OT被认为是一种潜在的治疗涉及社会行为缺陷的精神障碍的方法。然而，加班效应在不同个体之间往往是不同的。在这里，我们探索催产素受体基因rs53576多态对社会合作神经反应的OT影响的个体差异。在此之前，我们进行了一项双盲、安慰剂对照研究，将健康男性和女性随机分成两组，分别接受鼻腔催产素或安慰剂治疗。之后，他们在与同性伴侣玩重复的囚徒困境游戏时，接受了功能磁共振成像。在左侧尾状核腹侧，鼻腔注射催产素可增加男性对往复合作的激活，但对女性则倾向于减少激活。在这里，我们表明这些OT效应的性别差异是rs53576 GG基因个体特有的，而在其他基因类型(rs53576 AA/AG)中没有发现。因此，OT可能增加男性GG纯合子的积极社会互动的奖赏或显著，而减少女性GG纯合子的这些过程。这些结果表明，rs53576基因型是未来鼻腔OT治疗临床疗效研究中需要考虑的一个重要变量。
Intranasal oxytocin (OT) can modulate social-emotional functioning and related brain activity in humans. Consequently, OT has been discussed as a potential treatment for psychiatric disorders involving social behavioral deficits. However, OT effects are often heterogeneous across individuals. Here we explore individual differences in OT effects on the neural response to social cooperation as a function of the rs53576 polymorphism of the oxytocin receptor gene (OXTR). Previously, we conducted a double-blind, placebo-controlled study in which healthy men and women were randomized to treatment with intranasal OT or placebo. Afterwards, they were imaged with fMRI while playing an iterated Prisoner’s Dilemma Game with same-sex partners. Within the left ventral caudate nucleus, intranasal OT treatment increased activation to reciprocated cooperation in men, but tended to decrease activation in women. Here, we show that these sex differences in OT effects are specific to individuals with the rs53576 GG genotype, and are not found for other genotypes (rs53576 AA/AG). Thus, OT may increase the reward or salience of positive social interactions for male GG homozygotes, while decreasing those processes for female GG homozygotes. These results suggest that rs53576 genotype is an important variable to consider in future investigations of the clinical efficacy of intranasal OT treatment.