Enabling Wittig reaction on site-specific protein modification
Enabling Wittig reaction on site-specific protein modification
复制标题
实现位点特异性蛋白质修饰的 Wittig 反应
DOI：
10.1039/c2cc35738k
复制
发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Ye, Xin-Shan
中科院分区：
文献类型：
--
作者：
Han, Ming-Jie;Xiong, De-Cai;Ye, Xin-Shan
首次在蛋白质生物偶联上实现了高效的水相Wittig反应。通过对小分子、多肽和蛋白质的反应研究，提出了一种以“醛标签”为靶点的位点特异性反应。可以将各种官能团引入到感兴趣的蛋白质中。
An efficient aqueous Wittig reaction was enabled on protein bioconjugation for the first time. By investigating the reaction on small molecules, peptides, and proteins, a site-specific reaction targeting "aldehyde tag'' was presented. A variety of functional groups could be introduced into the protein of interest.