Successful intermittent treatment of smear-positive pulmonary tuberculosis in six months: a cooperative study in Poland.
Successful intermittent treatment of smear-positive pulmonary tuberculosis in six months: a cooperative study in Poland.
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六个月内成功间歇治疗涂阳肺结核：波兰的一项合作研究。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
M. Long
中科院分区：
文献类型：
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作者：
D. Snider;J. Rogowski;M. Zierski;E. Bek;M. Long
119例年龄在15 ~ 70岁之间的患者，均为痰涂片阳性，既往未接受过治疗的肺结核，接受了6个月的异烟肼和利福平治疗方案，在最初的2个月内补充链霉素和吡嗪酰胺。在最初的2个月内，每天在医院给予4种药物，随后在接下来的4个月内，每周两次在门诊给予异烟肼和利福平。19例患者出现药物不良反应，但只有6例出现毒性反应，需要停药7天或更长时间。3例毒性反应归因于链霉素，2例归因于利福平，1例归因于异烟肼，无归因于吡嗪酰胺。119例合格患者中有85例（71%）完成了治疗。治疗前2个月后，91%的患者痰培养阴性，所有患者在治疗第3个月结束时痰培养阴性。在治疗完成后观察18个月的84名患者中没有复发。
One hundred nineteen patients 15 to 70 yr of age, all with smear-positive, previously untreated, pulmonary tuberculosis, were treated with a 6-month regimen containing isoniazid and rifampin, supplemented during the initial 2 months with streptomycin and pyrazinamide. The 4 drugs were administered daily in the hospital during the initial 2 months, followed by isoniazid and rifampin administered twice weekly on an outpatient basis during the next 4 months. Adverse reactions to the drugs were seen in 19 patients, but only 6 had toxic reactions requiring withdrawal of drugs for 7 days or more. Three of the toxic reactions were attributed to streptomycin, 2 to rifampin, 1 to isoniazid, and none to pyrazinamide. Eighty-five (71%) of the 119 eligible patients completed treatment. After the first 2 months of therapy, 91% of these patients had negative sputum cultures, and all of them had negative cultures by the end of the third month of treatment. No relapses have occurred among the 84 patients observed for 18 months after therapy was completed.