Cell-Size Control.
Cell-Size Control.
复制标题
DOI：
10.1101/cshperspect.a019083
复制
发表时间：
2016-04-01
影响因子：
7.2
通讯作者：
Skotheim JM
中科院分区：
文献类型：
--
作者：
Amodeo AA;Skotheim JM
给定类型的细胞保持特征细胞大小，以在其生态或生物体环境中有效地发挥作用。它们通过调节生长速率或通过主动感知大小并将此信号与细胞分裂耦合来实现这一点。我们重点审查潜在的尺寸感应机制，包括几何，外部线索，和滴定机制。针对DNA滴定蛋白质的机制特别令人感兴趣，因为它们与DNA含量和细胞大小的稳健相关性一致。我们回顾了文献，这表明滴定机制可能是非洲爪蟾胚胎，芽殖酵母和大肠杆菌细胞大小传感的基础，而替代机制可能在裂变酵母中发挥作用。
Cells of a given type maintain a characteristic cell size to function efficiently in their ecological or organismal context. They achieve this through the regulation of growth rates or by actively sensing size and coupling this signal to cell division. We focus this review on potential size-sensing mechanisms, including geometric, external cue, and titration mechanisms. Mechanisms that titrate proteins against DNA are of particular interest because they are consistent with the robust correlation of DNA content and cell size. We review the literature, which suggests that titration mechanisms may underlie cell-size sensing in Xenopus embryos, budding yeast, and Escherichia coli, whereas alternative mechanisms may function in fission yeast.