MODE OF PROVIRAL ACTIVATION OF A PUTATIVE MAMMARY ONCOGENE (INT-1) ON MOUSE CHROMOSOME-15
MODE OF PROVIRAL ACTIVATION OF A PUTATIVE MAMMARY ONCOGENE (INT-1) ON MOUSE CHROMOSOME-15
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DOI：
10.1038/307131a0
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发表时间：
1984-01-01
期刊：
影响因子：
64.8
通讯作者：
VARMUS, H
中科院分区：
文献类型：
--
作者：
NUSSE, R;VANOOYEN, A;VARMUS, H
大多数由小鼠乳腺肿瘤病毒（MMTV）在C3 H小鼠中诱导的乳腺癌在15号染色体上的高度保守位点（称为int-1）内具有新的前病毒插入。该基因座内的转录单位在所有测试的正常组织中无活性，但在乳腺肿瘤中以低水平表达，前病毒插入位于基因的5“或3”侧。转录的前病毒收益远离int-1，因此，一个间接的机制似乎激活这个假定的癌基因的表达。
Most mammary carcinomas induced in C3H mice by the mouse mammary tumor virus (MMTV) bear a new proviral insertion within a highly conserved locus on chromosome 15 called int-1. A transcriptional unit within this locus is inactive in all tested normal tissues but expressed at low levels in mammary tumors with proviral insertions positioned on either the 5'' or 3'' sides of the gene. Transcription of the proviruses proceeds away from int-1; thus, an indirect mechanism appears to activate expression of this putative oncogene.