Consensus Paper: Experimental Neurostimulation of the Cerebellum
Consensus Paper: Experimental Neurostimulation of the Cerebellum
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DOI：
10.1007/s12311-019-01041-5
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发表时间：
2019-12-01
期刊：
影响因子：
3.5
通讯作者：
Sillitoe, Roy V.
中科院分区：
文献类型：
--
作者：
Miterko, Lauren N.;Baker, Kenneth B.;Sillitoe, Roy V.
小脑以其在控制运动行为中的作用而闻名。然而，最近的研究支持这样的观点，即它也影响非运动行为。小脑对不同脑功能的贡献通过其参与多种多样且越来越多的神经和神经精神病症而得到强调，所述神经和神经精神病症包括共济失调、肌张力障碍、特发性震颤、帕金森病（PD）、癫痫、中风、多发性硬化症、自闭症谱系障碍、阅读障碍、注意缺陷多动障碍（ADHD）和精神分裂症。虽然这些病症没有治愈方法，但小脑刺激正在迅速引起人们对症状缓解的关注，因为小脑回路已经成为侵入性和非侵入性神经调节的有希望的靶点。这篇共识论文汇集了来自神经生理学，神经病学和神经外科领域的专家，讨论了最近使用小脑作为治疗干预的努力。我们报告了在人类和动物模型中操纵小脑回路的最先进技术，并定义了前进的关键障碍和问题。
The cerebellum is best known for its role in controlling motor behaviors. However, recent work supports the view that it also influences non-motor behaviors. The contribution of the cerebellum towards different brain functions is underscored by its involvement in a diverse and increasing number of neurological and neuropsychiatric conditions including ataxia, dystonia, essential tremor, Parkinson's disease (PD), epilepsy, stroke, multiple sclerosis, autism spectrum disorders, dyslexia, attention deficit hyperactivity disorder (ADHD), and schizophrenia. Although there are no cures for these conditions, cerebellar stimulation is quickly gaining attention for symptomatic alleviation, as cerebellar circuitry has arisen as a promising target for invasive and non-invasive neuromodulation. This consensus paper brings together experts from the fields of neurophysiology, neurology, and neurosurgery to discuss recent efforts in using the cerebellum as a therapeutic intervention. We report on the most advanced techniques for manipulating cerebellar circuits in humans and animal models and define key hurdles and questions for moving forward.