Molecular Signatures of the Three Stem Cell Lineages in Hydra and the Emergence of Stem Cell Function at the Base of Multicellularity
Molecular Signatures of the Three Stem Cell Lineages in Hydra and the Emergence of Stem Cell Function at the Base of Multicellularity
复制标题
DOI：
10.1093/molbev/mss134
复制
发表时间：
2012-11-01
影响因子：
10.7
通讯作者：
Bosch, Thomas C. G.
中科院分区：
文献类型：
--
作者：
Hemmrich, Georg;Khalturin, Konstantin;Bosch, Thomas C. G.
不同的干细胞群体如何起源，以及是否存在明确的干细胞“遗传特征”仍然知之甚少。理解干细胞的进化需要在动物中干细胞的基础系统发育位置上进行分子分析。在这项研究中，使用转基因水螅息肉，我们揭示了三个干细胞群体中的每一个特定的签名集的转录因子和基因在细胞类型特异性功能和谱系间通信中发挥关键作用。我们的数据表明，干细胞基因的主要功能，如维持干细胞和控制干细胞自我更新和分化，出现在后生动物进化的早期。他们证实了干细胞类型共享共同的多功能祖先的观点，这些祖先通过子细胞功能的逐步分离实现了复杂性。
How distinct stem cell populations originate and whether there is a clear stem cell "genetic signature" remain poorly understood. Understanding the evolution of stem cells requires molecular profiling of stem cells in an animal at a basal phylogenetic position. In this study, using transgenic Hydra polyps, we reveal for each of the three stem cell populations a specific signature set of transcriptions factors and of genes playing key roles in cell type-specific function and interlineage communication. Our data show that principal functions of stem cell genes, such as maintenance of stemness and control of stem cell self-renewal and differentiation, arose very early in metazoan evolution. They are corroborating the view that stem cell types shared common, multifunctional ancestors, which achieved complexity through a stepwise segregation of function in daughter cells.