Zwitterionic Molecularly Imprinted Cross-Linked Micelles for Alkaloid Recognition in Water
Zwitterionic Molecularly Imprinted Cross-Linked Micelles for Alkaloid Recognition in Water
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DOI：
10.1021/acs.joc.9b01629
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发表时间：
2019-11-01
影响因子：
3.6
通讯作者：
Zhao, Yan
中科院分区：
文献类型：
--
作者：
Duan, Likun;Zhao, Yan
表面/核心双交联胶束内的分子印迹为其模板分子提供了水溶性纳米粒子受体。一致地观察到极强的印迹效果，与不使用模板制备的非印迹纳米颗粒相比，印迹因子 >100:1。可交联表面活性剂的离子性质强烈影响压印和粘合过程。当模板为两性离子或阳离子时，用两性离子可交联表面活性剂 (4) 制备的印迹受体优于类似的阳离子表面活性剂 (1)，并且无论其离子特性如何，它们的模板优于结构类似物。然而，静电相互作用主导了用阳离子表面活性剂制成的受体。同样的胶束印记适用于简单和复杂的生物碱。 4 种印记受体还可以根据结构相似性对生物碱客体进行分类。
Molecular imprinting within surface/core doubly cross-linked micelles afforded water-soluble nanoparticle receptors for their template molecules. Extremely strong imprinting effects were consistently observed, with the imprinting factor >100:1 in comparison to nonimprinted nanoparticles prepared without the templates. The ionic nature of the cross-linkable surfactant strongly impacted the imprinting and binding process. Imprinted receptors prepared with a zwitterionic cross-linkable surfactant (4) outperformed a similar cationic one (1) when the template was zwitterionic or cationic and preferred their templates over structural analogues regardless of their ionic characteristics. Electrostatic interactions, however, dominated the receptors made with the cationic surfactant. The same micellar imprinting applied to simple as well as complex alkaloids. Imprinted receptors from 4 were also shown to categorize their alkaloid guests according to their structural similarity.