A universal vaccine for serogroup B meningococcus
A universal vaccine for serogroup B meningococcus
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DOI：
10.1073/pnas.0603940103
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发表时间：
2006-07-18
影响因子：
11.1
通讯作者：
Pizza, Mariagrazia
中科院分区：
文献类型：
--
作者：
Giuliani, Marzia M.;Adu-Bobie, Jeannette;Pizza, Mariagrazia
由B群脑膜炎球菌引起的脑膜炎和败血症是两种严重的疾病，仍然导致大量死亡。到目前为止，还没有通用的疫苗来预防这些疾病。在这项工作中，反向疫苗学发现的五种抗原以适合大规模生产的形式表达，并使用适合人类使用的佐剂配制。氢氧化铝佐剂的疫苗在小鼠中诱导了针对代表全球种群多样性的85种脑膜炎双球菌菌株中78%的杀菌抗体。加入CpG寡核苷酸或以MF59为佐剂，菌种覆盖率可提高到90%以上。这种疫苗有可能攻克儿童时期最具破坏性的疾病之一。
Meningitis and sepsis caused by serogroup B meningococcus are two severe diseases that still cause significant mortality. To date there is no universal vaccine that prevents these diseases. In this work, five antigens discovered by reverse vaccinology were expressed in a form suitable for large-scale manufacturing and formulated with adjuvants suitable for human use. The vaccine adjuvanted by aluminum hydroxide induced bactericidal antibodies in mice against 78% of a panel of 85 meningococcal strains representative of the global population diversity. The strain coverage could be increased to 90% and above by the addition of CpG oligonucleoticles or by using MF59 as adjuvant. The vaccine has the potential to conquer one of the most devastating diseases of childhood.