Long-acting reversible contraception by effervescent microneedle patch
Long-acting reversible contraception by effervescent microneedle patch
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DOI：
10.1126/sciadv.aaw8145
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发表时间：
2019-11-01
期刊：
影响因子：
13.6
通讯作者：
Prausnitz, Mark R.
中科院分区：
文献类型：
--
作者：
Li, Wei;Tang, Jie;Prausnitz, Mark R.
为了增加获得长效避孕药的机会，我们开发了一种可逆避孕微针贴片，该贴片易于使用，可在 1 个月以上的时间内缓慢释放避孕激素（左炔诺孕酮），并且不会产生具有生物危害的尖锐废物。手动将贴片按压到皮肤上 1 分钟后，由于与皮肤间质液接触引发泡腾，微针迅速从皮肤内的贴片分离，这一点在大鼠和人类参与者中得到了证明。长效避孕是通过用可生物降解的聚合物[聚乳酸-乙醇酸]配制微针来实现的，该聚合物在体外缓慢释放左炔诺孕酮约1个月。在大鼠中，贴剂将左炔诺孕酮浓度维持在人类避孕阈值水平以上超过 1 个月，而安慰剂微针贴剂在人类参与者中具有良好的耐受性。三大洲的育龄妇女表现出对微针贴片长效避孕的兴趣和偏好。这些研究表明，泡腾微针贴片可以促进更多人获得长效避孕药。
To increase access to long-acting contraception, we developed a reversible contraceptive microneedle patch that is simple-to-administer, slowly releases contraceptive hormone (levonorgestrel) for >1 month, and generates no biohazardous sharps waste. After manually pressing the patch to skin for 1 min, microneedles rapidly separate from the patch within the skin due to effervescence triggered by contact with skin's interstitial fluid, as demonstrated in rats and human participants. Long-acting contraception is achieved by formulating microneedles with a biodegradable polymer [poly(lactic-co-glycolic) acid] that slowly releases levonorgestrel for similar to 1 month in vitro. In rats, the patch maintained levonorgestrel concentration above the human contraceptive threshold level for >1 month, and a placebo micro-needle patch was well-tolerated in human participants. Women of reproductive age in three continents demonstrated interest in and preference for long-acting contraception by microneedle patch. These studies indicate that an effervescent microneedle patch could facilitate greater access to long-acting contraception.