Cyclooxygenase-2 immunoreactivity in depressed-type colorectal adenomas and cancers.
Cyclooxygenase-2 immunoreactivity in depressed-type colorectal adenomas and cancers.
复制标题
抑郁型结直肠腺瘤和癌症中的环加氧酶 2 免疫反应性。
DOI：
10.3892/or.7.6.1217
复制
发表时间：
2000
期刊：
影响因子：
4.2
通讯作者：
M. Mori
中科院分区：
文献类型：
--
作者：
K. Saito;K. Arai;M. Mori
为了阐明环氧合酶-2免疫反应性与抑郁型结直肠腺瘤和癌的进展之间的关系，我们检测了抑郁型结直肠腺瘤和癌中环氧合酶-2的表达。免疫组化染色采用链霉亲和素-生物素法。在100例腺瘤中，15例为凹陷型，凹陷型中未检测到环氧合酶-2的表达，凹陷型的病灶大小与其他类型的差异无统计学意义。100例黏膜下浸润性癌中，14例为凹陷型，凹陷型中未检测到环氧合酶-2的表达，凹陷型肿瘤的病灶大小与其他类型无明显差异。在100例侵犯固有肌层的癌中，凹陷型15例，凹陷型中未检测到环氧合酶-2表达，这些癌的病灶明显小于其他癌（p<0.05）。我们的研究结果表明，抑郁型癌症不导致环氧合酶-2的表达。
In order to clarify the relationship of the cyclooxygenase-2 immunoreactivity and the progression of depressed-type colorectal adenomas and cancers, we examined cyclooxygenase-2 expression in depressed-type colorectal adenomas and cancers. Immunohistochemical staining was performed by the streptavidin-biotin method. Among 100 adenomas, depressed-type were found in 15, cyclooxygenase-2 expression was not detected in depressed-types, and lesion size in depressed-types did not differ from that in others. Among 100 submucosal invasive cancers, depressed-type were found in 14, cyclooxygenase-2 expression was not detected in depressed-types, and lesion size in tumor with depressed-type did not differ from that in others. Among 100 cancers invading the muscularis propria, depressed-types in 15, cyclooxygenase-2 expression was not detected in depressed-types; these were significantly smaller lesions than those in others (p<0.05). Our results suggest that depressed-type cancers do not result from cyclooxygenase-2 expression.