Innovations in Instrumentation for Positron Emission Tomography.
Innovations in Instrumentation for Positron Emission Tomography.
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DOI：
10.1053/j.semnuclmed.2018.02.006
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发表时间：
2018-07
影响因子：
4.9
通讯作者：
Cherry SR
中科院分区：
文献类型：
--
作者：
Berg E;Cherry SR
正电子发射断层扫描（PET）扫描仪是精密和高灵敏度的生物医学成像设备，可以产生高度定量的图像，显示体内放射性示踪剂的三维分布。PET扫描仪通常与X射线计算机断层扫描（CT）或磁共振成像（MRI）扫描仪集成在混合设备中，可以提供分子成像（PET）和解剖成像（CT或MRI）。尽管经过了数十年的发展，但仍存在重大机会，可以在各种临床和研究任务中对PET系统的性能进行重大改进。这些机会来自新的想法和概念，以及一系列使能技术和方法。在本文中，我们回顾了PET仪器，探测器和系统的最新技术水平，描述了目前实践中PET的主要局限性，并对我们认为将影响该领域的一些最新和新兴技术创新提供了我们自己的见解。我们的重点是PET成像的技术方面，特别是探测器和系统设计，以及接近PET系统的机会和必要性，用于诊断患者和体内生物医学研究，真正接近物理性能极限，同时注意成像时间，辐射剂量和成本。然而，这里没有涉及的其他关键工作，包括重建和建模方法的创新，放射性示踪剂的开发以及扩大临床和研究应用范围，也将在定义该领域的未来方面发挥同样重要的作用。
Positron emission tomography (PET) scanners are sophisticated and highly sensitive biomedical imaging devices that can produce highly quantitative images showing the three-dimensional distribution of radiotracers inside the body. PET scanners are commonly integrated with x-ray computed tomography (CT) or magnetic resonance imaging (MRI) scanners in hybrid devices that can provide both molecular imaging (PET) and anatomical imaging (CT or MRI). Despite decades of development, significant opportunities still exist to make major improvements in the performance of PET systems for a variety of clinical and research tasks. These opportunities stem from new ideas and concepts, as well as a range of enabling technologies and methodologies. In this paper, we review current state of the art in PET instrumentation, detectors and systems, describe the major limitations in PET as currently practiced, and offer our own personal insights into some of the recent and emerging technological innovations that we believe will impact the field. Our focus is on the technical aspects of PET imaging, specifically detectors and system design, and the opportunity and necessity to move closer to PET systems for diagnostic patient use and in vivo biomedical research that truly approach the physical performance limits while remaining mindful of imaging time, radiation dose and cost. However, other key endeavors which are not covered here, including innovations in reconstruction and modeling methodology, radiotracer development, and expanding the range of clinical and research applications, also will play an equally important, if not more important, role in defining the future of the field.
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影响因子：
1.8
作者：
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通讯作者：
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通讯作者：
Cherry SR