Primary cytomegalovirus infection following cardiac transplantation in a murine model.
Primary cytomegalovirus infection following cardiac transplantation in a murine model.
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小鼠模型心脏移植后的原发性巨细胞病毒感染。
DOI：
10.1097/00007890-198403000-00018
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发表时间：
1984
期刊：
影响因子：
6.2
通讯作者：
Medearis,DN
中科院分区：
文献类型：
--
作者：
Rubin,RH;Wilson,EJ;Barrett,LV;Medearis,DN
利用小鼠巨细胞病毒（CMV）3模型来确定心脏移植中原发CMV感染的来源。从活动性或潜伏性感染的BALB/C小鼠中取出心脏，然后作为原发性异位同种移植物移植到CMV阴性的BALB/C小鼠中。从急性感染供体的心脏移植到非免疫抑制的受体，导致无症状的初次感染，表现为供体和受体的心脏、肝脏、脾脏和唾液腺中都可检测到病毒，并产生抗CMV抗体。当从潜伏感染的动物的心脏移植到nonimmunosuppressed收件人，一个短暂的原发性感染发生，表现为可检测到的病毒在脾脏和唾液腺和抗CMV抗体的外观。
A murine cytomegaloviris (CMV) 3 model was utilized to determine the source of primary CMV infection in cardiac transplantation. Hearts were taken from actively or latently infected BALB/C mice and then transplanted as primary, heterotopic isografts into CMV-negative BALB/C recipiens. The transplnantation of hearth from acutely infected donors into nonimmuno-suppressed recipients resulted in asymptomatic priamry infection as manifested by detectable virus in both donor and recipient hearts, liver, spleen, and salivary glands and by the development of anti-CMV antibody. When hearts from latently infected animals were transplanted into nonimmunosuppressed recipients, a transient primary infection occurred that was manifested by detectable virus in the spleen and salivary glands and the appearance of anti-CMV antibody.