Vitamin D Deficiency: A Potential Modifiable Risk Factor for Cardiovascular Disease in Children with Severe Obesity
Vitamin D Deficiency: A Potential Modifiable Risk Factor for Cardiovascular Disease in Children with Severe Obesity
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DOI：
10.3390/children4090080
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发表时间：
2017-09-01
期刊：
影响因子：
2.4
通讯作者：
Kumar, Seema
中科院分区：
文献类型：
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作者：
Iqbal, Anoop Mohamed;Dahl, Amanda R.;Kumar, Seema
严重肥胖与血脂异常和心血管疾病风险增加有关。肥胖是维生素 D 缺乏的危险因素。我们研究了重度肥胖儿童的 25-羟基维生素 D (25(OH)D) 浓度与血脂之间的关系。审查了 376 名儿童的医疗记录。在调整年龄、性别、抽血季节、体重指数 (BMI) z 分数和第 95 个百分位的 BMI % 后，使用线性回归模型和逻辑回归来检查 25(OH)D 与血脂之间的关系。 376 名儿童中有 263 名 (70%) 的 25(OH)D 浓度 < 30 ng/mL。 25(OH)D 浓度与高密度脂蛋白胆固醇 (HDL-C) 浓度呈正相关 (r(2) = 0.08，r = 0.22，β = 0.16，95% CI = 0.05-0.27，p = 0.004）。与 25(OH)D 30 ng/mL (n = 113) 的儿童相比，25(OH)D < 30 ng/mL (n = 263) 的 HDL-C 较低（41.3 +/- 10.2 与 46.4 +/- 12 mg/dL，p < 0.0001）。 25(OH)D 浓度 < 30 ng/mL 的儿童出现低 HDL-C 的调整后几率更大（
Severe obesity is associated with abnormal lipids and increased risk for cardiovascular disease. Obesity is a risk factor for vitamin D deficiency. We examined relationship between 25-hydroxy vitamin D (25(OH)D) concentrations and lipids in children with severe obesity. Medical records of 376 children were reviewed. Linear regression models and logistic regression were used to examine the relationship between 25(OH)D and lipids after adjustment for age, gender, season of blood draw, body mass index (BMI) z-score, and BMI % of 95th percentile. Two-hundred sixty-three out of 376 children (70%) had 25(OH)D concentrations < 30 ng/mL. Concentrations of 25(OH)D were positively correlated with those of high-density lipoprotein cholesterol (HDL-C) (r(2) = 0.08, r = 0.22, beta = 0.16, 95% CI = 0.05-0.27, p = 0.004). HDL-C was lower in children with 25(OH)D < 30 ng/mL (n = 263) compared to those with 25(OH)D 30 ng/mL (n = 113) (41.3 +/- 10.2 vs. 46.4 +/- 12 mg/dL, p < 0.0001). Children with 25(OH)D concentrations < 30 ng/mL had greater adjusted odds of low HDL-C (