Oral capture and grasping of an artificial nipple by rat fetuses.
Oral capture and grasping of an artificial nipple by rat fetuses.
复制标题
大鼠胎儿对人工乳头的口腔捕获和抓握。
DOI：
10.1002/dev.420250802
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发表时间：
1992
影响因子：
2.2
通讯作者：
Murrish,DE
中科院分区：
文献类型：
--
作者：
Robinson,SR;Hoeltzel,TC;Cooke,KM;Umphress,SM;Smotherman,WP;Murrish,DE
虽然出生时失明和失聪，新生大鼠表现出显着的能力，认识和获得的乳头哺乳期的母亲。然而，众所周知，足月大鼠新生儿不会附着在人工乳头上。在本研究中，将由软乙烯基制成的人工乳头提供给妊娠E17-E21的大鼠胎仔。胎仔在E18时表现出左右头部运动，导致乳头被口腔捕获，并从E19至足月表现出直接乳头抓握反应。对E21大鼠胎仔录像带记录的逐帧分析显示，与人工乳头的触觉接触引起吸吮、直接舔乳头、前肢摆动和抓握乳头。胎仔还表现出厌恶行为的组成部分，包括面部擦拭和头部转动，这似乎终止了与乳头的口腔接触。吗啡预处理减少了厌恶反应的表达，促进了对人工乳头的舔和抓。除了记录这一重要的新生儿行为的产前个体发育，这些研究结果意味着内源性阿片类药物在新生大鼠的第一次哺乳事件中的作用。© 1992 Wiley & Sons. Inc.
Although born blind and deaf, newborn rats exhibit a remarkable capacity to recognize and gain access to the nipples of the lactating mother. However, it is well‐known that full‐term rat neonates will not attach to an artificial nipple. In the present study, an artificial nipple fashioned from soft vinyl was presented to rat fetuses from E17‐E21 of gestation. Fetuses showed side‐to‐side head movements that resulted in oral capture of the nipple on E18 and exhibited a direct nipple‐grasping response from E19 through term. Frame‐by‐frame analysis of videotape records of E21 rat fetuses revealed that tactile contact with the artificial nipple elicited mouthing, licking directed at the nipple, forelimb treadling, and grasping of the nipple. Fetuses also exhibited components of aversive behavior, including facial wiping and head turning, that appeared to terninate oral contact with the nipple. Morphine pretreatment reduced the expression of aversive responses and promoted licking and grasping of the artificial nipple. In addition to documenting the prenatal ontogeny of this important neonatal behavior, these findings imply a role for endogenous opioids in the newborn rat's first suckling episode. © 1992 Wiley & sons. Inc.