Differential diagnosis of sporadic adult-onset ataxia: The role of REM sleep behavior disorder.
Differential diagnosis of sporadic adult-onset ataxia: The role of REM sleep behavior disorder.
复制标题
成人散发性共济失调的鉴别诊断：快速眼动睡眠行为障碍的作用。
DOI：
10.1016/j.parkreldis.2015.04.001
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发表时间：
2015
影响因子：
4.1
通讯作者：
R. Munhoz
中科院分区：
文献类型：
--
作者：
H. Teive;W. Arruda;A. Moro;M. Moscovich;R. Munhoz
研究背景：成人型散发性共济失调是一组退行性、非遗传性疾病，包括特发性成人型共济失调和小脑型多系统萎缩。我们的目的是分析诊断在后续的50散发成人发作性共济失调patients.MethodsClinical和实验室检查结果的50例成人散发性共济失调进行了分析。可能的快速眼动睡眠行为障碍的诊断主要是基于临床公认的criteria. Results48%的情况下，多系统萎缩的诊断，其余52%收到了散发性成人发作性共济失调的诊断。46%的患者被诊断为REM睡眠行为障碍。而在可能有多系统萎缩的患者中，相应的数字为83.34%，而在散发性共济失调患者中为11.53%（P < 0.001）。结论REM睡眠行为障碍是鉴别多系统萎缩与散发性成人发作性共济失调的重要辅助手段，应鼓励其用于此目的。
BackgroundSporadic adult-onset ataxia encompasses a group of degenerative, non-hereditary disorders, including idiopathic adult-onset ataxia and the cerebellar form of multiple system atrophy. Our objective was to analyze the diagnosis at follow-up of 50 sporadic adult-onset ataxia patients.MethodsClinical and laboratory findings of 50 adult patients with sporadic adult-onset ataxia were analyzed. Diagnosis of probable REM sleep behavior disorder was based predominantly on clinically accepted criteria.ResultsMultiple system atrophy was diagnosed in 48% of cases, the remaining 52% received a diagnosis of sporadic adult-onset ataxia. REM sleep behavior disorder was diagnosed in 46% of the patients. However, among patients with probable multiple system atrophy, the corresponding figure was 83.34% versus 11.53% among those with sporadic ataxia (p < 0.001).ConclusionsREM sleep behavior disorder is an important aid to the differentiation of multiple system atrophy from sporadic adult-onset ataxia and its use for this purpose should be encouraged.