Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina
Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina
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DOI：
10.1161/01.cir.98.22.2370
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发表时间：
1998-12-01
期刊：
影响因子：
37.8
通讯作者：
Maseri, A
中科院分区：
文献类型：
--
作者：
Liuzzo, G;Buffon, A;Maseri, A
背景--在不稳定型心绞痛中发现了炎症的系统性标记物。与稳定型心绞痛患者相比，不稳定型心绞痛患者冠脉狭窄的破坏可能会引起更大的炎症反应。我们观察了30例稳定型心绞痛和56例不稳定型心绞痛患者经皮冠状动脉腔内成形术(PTCA)后C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)和白介素6(IL-6)的变化。方法和结果：于PTCA或冠状动脉造影术后6、24、48、72小时采集外周血，A方案中87%的稳定型患者和29%的不稳定型心绞痛患者的基础CRP、SAA和IL-6水平正常。PTCA术后基础值正常的稳定型患者和不稳定型患者的CRP、SAA和IL-6水平无明显变化，而基线水平升高的不稳定型患者的血清CRP、SAA和IL-6水平升高(均P
Background-Systemic markers of inflammation have been found in unstable angina. Disruption of culprit coronary stenoses may cause a greater inflammatory response in patients with unstable than those with stable angina. We assessed the time course of C-reactive protein (CRP), serum amyloid A protein (SAA), and interleukin-6 (IL-6) after single-vessel PTCA in 30 patients with stable and 56 patients with unstable angina (protocol A). We also studied 12 patients with stable and 15 with unstable angina after diagnostic coronary angiography (protocol B).Methods and Results-Peripheral blood samples were taken before and 6, 24, 48, and 72 hours after PTCA or angiography, In protocol A, baseline CRP, SAA, and LL-6 levels were normal in 87% of stable and 29% of unstable patients. After PTCA, CRP, SAA, and IL-6 did not change in stable patients and unstable patients with normal baseline levels but increased in unstable patients with raised baseline levels (all P