Genes that control the development of migrating muscle precursor cells
Genes that control the development of migrating muscle precursor cells
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DOI：
10.1016/s0955-0674(00)00159-9
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发表时间：
2000-12-01
影响因子：
7.5
通讯作者：
Brohmann, H
中科院分区：
文献类型：
--
作者：
Birchmeier, C;Brohmann, H
尽管脊椎动物的骨骼肌在功能和生化方面相似，但它们是通过不同的发育机制产生的。下轴肌群的一个主要亚类源自从皮肌切层上分层的远程迁移祖细胞。该谱系的发育由 Pax3、c-Met 酪氨酸激酶受体、其配体 SF/HGF（分散因子/肝细胞生长因子）和同源框因子 Lbx1 控制。这些分子对于前体库的建立、分层、迁移和目标发现至关重要。在理解肌肉的模式方面已经取得了进展，这需要精确控制肌源性前体细胞的增殖和分化。
Skeletal muscles in vertebrates, despite their functional and biochemical similarities, are generated via diverse developmental mechanisms. A major subclass of hypaxial muscle groups is derived from long-range migrating progenitor cells that delaminate from the dermomyotome. The development of this lineage is controlled by Pax3, the c-Met tyrosine kinase receptor, its ligand SF/HGF (scatter factor/hepatacyte growth factor) and the homeobox factor Lbx1. These molecules are essential for establishment of the precursor pool, delamination, migration and target finding. Progress has been made in understanding patterning of the muscles, which requires a precise control of proliferation and differentiation of myogenic precursor cells.