Association of the mitochondrial DNA haplogroup J with longevity is population specific
Association of the mitochondrial DNA haplogroup J with longevity is population specific
复制标题
DOI：
10.1038/sj.ejhg.5201278
复制
发表时间：
2004-12-01
影响因子：
5.2
通讯作者：
De Benedictis, G
中科院分区：
文献类型：
--
作者：
Dato, S;Passarino, G;De Benedictis, G
关于线粒体DNA（mtDNA）变异对许多复杂性状的影响的证据越来越多。特别是，mtDNA单倍群J已被报道增加个人的机会，达到长寿的北方意大利人，北方爱尔兰人和芬兰人。然而，由于长寿的遗传贡献可能是特定的人群，我们想验证是否单倍群J也影响长寿在南欧人口具有不同的遗传和环境历史。我们分析了人口样本（883名受试者，371名男性和521名女性，年龄范围18-108岁）从南部意大利的单倍型群J的存在下，没有发现在老年人队列中的mtDNA单倍型群的频率增加，这表明，在这个人口中，单倍型群J不发挥重要作用的长寿。这一发现表明，与其他遗传因素一样，mtDNA遗传变异与长寿的关联具有群体特异性。
Evidences are accumulating on the effects of the variability of mitochondrial DNA (mtDNA) on many complex traits. In particular, mtDNA haplogroup J has been reported to increase the individual chance to attain longevity in northern Italians, Northern Irish and Finns. However, since the genetic contribution to longevity may be population specific, we wanted to verify if haplogroup J does affect longevity also in a southern European population having a different genetic and environmental history. We analysed a population sample (883 subjects, 371 males and 521 females; age range 18-108 years) from southern Italy for the presence of haplogroup J. No frequency increase of this mtDNA haplogroup was found in the older cohorts, suggesting that, in this population, haplogroup J does not play a significant role in longevity. This finding shows that, as for other genetic factors, the association of mtDNA inherited variability with longevity is population specific.