Testosterone enhances aggression of wild-type mice but not those deficient in type I 5α-reductase
Testosterone enhances aggression of wild-type mice but not those deficient in type I 5α-reductase
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DOI：
10.1016/s0006-8993(02)03076-7
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发表时间：
2002-09-06
期刊：
影响因子：
2.9
通讯作者：
Harney, JP
中科院分区：
文献类型：
--
作者：
Frye, CA;Rhodes, ME;Harney, JP
替吉奥（T）的攻击增强作用可能部分由其5 α-还原的3-羟基类固醇代谢产物5 α-雄甾烷-3 α，17 β-二醇（3 α-二醇）介导。为了验证这一假设，在实验。I性腺切除（gdx）的C21小鼠给予T，3 α-二醇或溶剂，并在1小时后的入侵者攻击测试中观察。给予雄激素的C21小鼠的攻击发生率显著高于给予溶剂的小鼠。在Expt. 2，野生型小鼠和5 α-还原酶I型酶缺陷的小鼠被给予T或载体，并在1小时后在常驻入侵者范例中进行测试。野生型小鼠给予T有显着较短的lavage和更大的发病率的侵略比5 α-还原酶I型敲除小鼠给予T或车辆管理的小鼠。数据来自Exp。I与T和3 α-二醇具有相似的攻击增强作用一致，并且实验I的结果与T和3 α-二醇具有相似的攻击增强作用一致。2表明，不能代谢T的5 α还原产物可能会减弱一些侵略增强的影响，小鼠在居民入侵者测试的侵略。(C)2002爱思唯尔科技有限公司。保留所有权利。
Testosterone's (T) aggression-enhancing effects may be mediated in part by its 5alpha-reduced, 3-hydroxysteroid dehydrogenized metabolite 5alpha-androstane-3alpha, 17beta-diol (3alpha-diol). To test this hypothesis, in Expt. I gonadectomized (gdx) C21 mice were administered T, 3alpha-diol, or vehicle and were observed in the resident intruder test of aggression 1 h later. C21 mice administered androgens had significantly higher incidences of aggression than did vehicle-administered mice. In Expt. 2, wild-type mice and mice deficient in the 5alpha-reductase type I enzyme were administered T or vehicle and tested I h later in the resident intruder paradigm. Wild-type mice administered T had significantly shorter latencies and greater incidences of aggression than did 5alpha-reductase type I knockout mice administered T or vehicle-administered mice. Data from Expt. I are consistent with T and 3alpha-diol having similar aggression-enhancing effects, and results of Expt. 2 suggest that the inability to metabolize T to its 5alpha-reduced products may attenuate some aggression-enhancing effects of mice in the resident intruder test of aggression. (C) 2002 Elsevier Science B.V. All rights reserved.