Biophysical and rheological biomarkers of red blood cell physiology and pathophysiology.
Biophysical and rheological biomarkers of red blood cell physiology and pathophysiology.
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DOI：
10.1097/moh.0000000000000639
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发表时间：
2021-05-01
影响因子：
3.2
通讯作者：
Gurkan UA
中科院分区：
文献类型：
--
作者：
Gurkan UA
这篇综述总结了红细胞生理学和病理生理学的重要生物物理学和流变学方面的最新进展，在微流体生物标志物测定和新兴的靶向或治疗意图的治疗。红细胞生物物理特性和血液流变学的改变与许多血液学和循环系统疾病有关。生物标志物测定的最新进展使得能够以临床上有意义的方式在常氧或生理缺氧中有效评估这些生物物理和流变学性质。有新兴的靶向或治愈性疗法，旨在改善红细胞病理生理学，特别是在遗传性血红蛋白疾病，如镰状细胞病的背景下。红细胞病理生理学可以作为治疗靶点，膜和细胞生物物理学以及血液流变学的改善现在可以通过新的微流体生物标志物测定进行可行的评估。最近的进展为主要的红细胞疾病提供了新的希望和新的治疗选择，包括遗传性血红蛋白疾病，膜疾病和其他红细胞疾病，如疟疾。
This review summarizes the significant biophysical and rheological aspects of red blood cell physiology and pathophysiology in relation to recent advances in microfluidic biomarker assays and emerging targeted or curative intent therapies. Alterations in red cell biophysical properties and blood rheology have been associated with numerous hematologic and circulatory disorders. Recent advances in biomarker assays enable effective assessment of these biophysical and rheological properties in normoxia or physiological hypoxia in a clinically meaningful way. There are emerging targeted or curative therapies that aim to improve red cell pathophysiology, especially in the context of inherited hemoglobin disorders, such as sickle cell disease. Red cell pathophysiology can be therapeutically targeted and the improvements in membrane and cellular biophysics and blood rheology can now be feasibly assessed via new microfluidic biomarker assays. Recent advances provide a new hope and novel treatment options for major red cell ailments, including inherited hemoglobin disorders, membrane disorders, and other pathologies of the red cell, such as malaria.