Characteristics of epigenetic aging across gestational and perinatal tissues.
Characteristics of epigenetic aging across gestational and perinatal tissues.
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DOI：
10.1186/s13148-021-01080-y
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发表时间：
2021-04-29
影响因子：
5.7
通讯作者：
Czamara D
中科院分区：
文献类型：
--
作者：
Dieckmann L;Lahti-Pulkkinen M;Kvist T;Lahti J;DeWitt PE;Cruceanu C;Laivuori H;Sammallahti S;Villa PM;Suomalainen-König S;Eriksson JG;Kajantie E;Raikkönen K;Binder EB;Czamara D
表观遗传时钟已经被用来显示相同年龄的个体之间的生物状态的差异。然而，到目前为止，只有很少的研究研究了新生儿的表观遗传老化--特别是关于不同的妊娠或围产期组织。在这项研究中，我们从两个独立的研究队列(国际电信联盟，n = 639和PREDO，n = 966)调查了哪些与出生和怀孕相关的变量在预测绒毛、胎盘和脐带血组织中孕期表观遗传年龄加速或减速(即从DNA甲基组估计的孕期表观遗传年龄与实际孕龄之间的偏差)中最重要。我们进一步描述了这些组织之间表观遗传年龄偏差的对应关系。在单个组织中，最能预测表观遗传年龄偏差的因素是孩子的性别、出生长度、怀孕期间母亲吸烟、母亲分娩前的精神障碍、分娩方式和产次。然而，与表观遗传年龄偏差和关联方向相关的特定因素在不同组织中是不同的。在样本来自不止一个组织的个体中，不同组织之间的相对表观遗传年龄偏差没有相关性。在所调查的组织中，孕期表观遗传年龄加速或减速与更多或更不利的因素在一个方向上没有关系，并且同一人组织之间的相对表观遗传年龄不同。这表明表观遗传年龄偏差与妊娠期和围产期不同的、特定于组织的因素有关。我们的发现表明，新生儿的表观遗传年龄应该被视为特定组织的特征，而不是孩子本身的一般特征。网上版载有补充材料，可在10.1186/s13148021-01080-y查阅。
Epigenetic clocks have been used to indicate differences in biological states between individuals of same chronological age. However, so far, only few studies have examined epigenetic aging in newborns—especially regarding different gestational or perinatal tissues. In this study, we investigated which birth- and pregnancy-related variables are most important in predicting gestational epigenetic age acceleration or deceleration (i.e., the deviation between gestational epigenetic age estimated from the DNA methylome and chronological gestational age) in chorionic villus, placenta and cord blood tissues from two independent study cohorts (ITU, n = 639 and PREDO, n = 966). We further characterized the correspondence of epigenetic age deviations between these tissues. Among the most predictive factors of epigenetic age deviations in single tissues were child sex, birth length, maternal smoking during pregnancy, maternal mental disorders until childbirth, delivery mode and parity. However, the specific factors related to epigenetic age deviation and the direction of association differed across tissues. In individuals with samples available from more than one tissue, relative epigenetic age deviations were not correlated across tissues. Gestational epigenetic age acceleration or deceleration was not related to more favorable or unfavorable factors in one direction in the investigated tissues, and the relative epigenetic age differed between tissues of the same person. This indicates that epigenetic age deviations associate with distinct, tissue specific, factors during the gestational and perinatal period. Our findings suggest that the epigenetic age of the newborn should be seen as a characteristic of a specific tissue, and less as a general characteristic of the child itself. The online version contains supplementary material available at 10.1186/s13148-021-01080-y.