The influence of crystal form on the radial stress transmission characteristics of pharmaceutical materials
The influence of crystal form on the radial stress transmission characteristics of pharmaceutical materials
复制标题
晶型对药用材料径向应力传递特性的影响
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
J. E. Carless
中科院分区：
文献类型：
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作者：
M. Summers;R. Enever;J. E. Carless
在单冲压片机中压制各种晶型的磺胺噻唑、巴比妥和阿司匹林，该压片机装有监测轴向施加和径向传递力以及上冲运动的仪器。在压缩循环过程中的径向应力的变化取决于压缩材料的多态形式。根据每种材料发生的塑性流动/破碎程度以及最终压坯经受弹性压缩的程度，对结果进行了合理化。据推测，磺胺噻唑和巴比妥的多晶型转变温度的降低以及磺胺噻唑II型的多晶型转变是由于晶体中位错的产生和压缩材料中形成的晶界处晶体的畸变。
Various crystal forms of sulphathiazole, barbitone and aspirin were compressed in a single‐punch tablet machine instrumented to monitor axially applied and radially transmitted forces, and upper punch movement. The changes in radial stress during the compression cycle depended upon the polymorphic form of the compressed material. The results were rationalized in terms of the degree of plastic flow/crushing that occurred with each material, and the degree to which the final compact underwent elastic compression. It is postulated that the reduction in the transition temperature of polymorphic forms of sulphathiazole and barbitone and the polymorphic transition of sulphathiazole Form II was due to the production of dislocations in the crystal and the distortion of the crystals at crystal boundaries formed in the compressed materials.