GLUCOCORTICOID RECEPTOR NUMBER AND CORTISOL EXCRETION IN MOOD, ANXIETY, AND PSYCHOTIC DISORDERS
GLUCOCORTICOID RECEPTOR NUMBER AND CORTISOL EXCRETION IN MOOD, ANXIETY, AND PSYCHOTIC DISORDERS
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DOI：
10.1016/0006-3223(93)90252-9
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发表时间：
1993-07-01
影响因子：
10.6
通讯作者：
GILLER, EL
中科院分区：
文献类型：
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作者：
YEHUDA, R;BOISONEAU, D;GILLER, EL
在本研究中，我们测定了重性抑郁症、双相躁狂症、创伤后应激障碍、惊恐障碍和精神分裂症患者的胞浆淋巴细胞糖皮质激素受体和24小时尿皮质醇排泄。与其他组患者相比，重度抑郁症患者每个细胞的糖皮质激素受体平均数量最少，创伤后应激障碍患者最多。双相躁狂和惊恐患者在淋巴细胞糖皮质激素受体数量方面没有差异。双相躁狂和惊恐患者的糖皮质激素受体/细胞明显多于精神分裂症患者。重性抑郁症和双相躁狂症患者的平均24小时尿皮质醇排泄量显著高于其他诊断组。淋巴细胞糖皮质激素受体数量和皮质醇排泄呈负相关，当整个样品被认为是一个整体，但这种影响并没有达到统计学意义。它的结论是，淋巴细胞糖皮质激素受体可能受到多种影响，而不仅仅是环境皮质醇水平的调制。这些初步数据表明，淋巴细胞糖皮质激素受体数量的评估与皮质醇水平可能提供一个更有意义的估计下丘脑-垂体-肾上腺轴的活动比单独使用皮质醇。
In the present study, we measured cytosolic lymphocyte glucocorticoid receptor and 24-hour urinary cortisol excretion in patients with major depressive disorder, bipolar mania, posttraumatic stress disorder, panic disorder, and schizophrenia. Patients with major depression had the smallest, and posttraumatic stress disordered patients the largest, mean number of glucocorticoid receptors per cell compared to patients in the other groups. Bipolar manic and panic patients did not differ from each other in regard to the number of lymphocyte glucocorticoid receptors. Bipolar manic and panic patients did have significantly more glucocorticoid receptors/cell than schizophrenic patients. The mean 24-hour urinary cortisol excretion was significantly higher in patients with major depression and bipolar mania than in those in the other diagnostic groups. Lymphocyte glucocorticoid receptor number and cortisol excretion tended to be inversely related, when the entire sample was considered as a whole, but this effect did not reach statistical significance. It is concluded that lymphocyte glucocorticoid receptors may be modulated by multiple influences, not just ambient cortisol levels. These preliminary data suggest that the assessment of lymphocyte glucocorticoid receptor number in tandem with cortisol levels may provide a more meaningful estimate of hypothalamic-pituitary-adrenal axis activity than is achieved using cortisol alone.