INVIVO QUANTITATIVE ULTRASONIC EVALUATION OF MYOCARDIAL FIBROSIS IN HUMANS
INVIVO QUANTITATIVE ULTRASONIC EVALUATION OF MYOCARDIAL FIBROSIS IN HUMANS
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DOI：
10.1161/01.cir.81.1.58
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发表时间：
1990-01-01
期刊：
影响因子：
37.8
通讯作者：
LABBATE, A
中科院分区：
文献类型：
--
作者：
PICANO, E;PELOSI, G;LABBATE, A
本研究的目的是在体内评估通过实时积分反向散射分析评估的区域超声反射率是否与通过心内膜心肌活检定量组织学评估的人类心肌中结缔组织的局部含量相关。通过具有定量集成反向散射分析功能的基于 M 模式的超声心动图系统对 16 名推定诊断为心肌病的患者进行了超声研究。使用 2.25 MHz 传感器。室间隔整流射频信号的积分值被视为积分反向散射指数，并以心包界面归一化百分比表示（假设为100%）。所有患者还接受了多次左心室心内膜心肌活检，用马森三色染色，并使用计算机辅助图像分析系统进行研究。当结缔组织面积大于 20%（8 名患者）时，积分反向散射指数百分比显着高于小于 20%（8 名患者）：51.+-。 25% 与 26 .+-. 11%，p < 0.05。积分反向散射指数百分比与结缔组织面积百分比之间存在显着相关性（p < 0.05，R = 0.55）。体内在线定量超声分析在人体中是可行的，并且可靠地识别人体心肌纤维化区域范围的变化。
The aim of this study was to assess in vivo whether the regional ultrasonic reflectivity, evaluated by a real-time integrated backscatter analysis, was related to the local content of connective tissue in human myocardium as estimated by quantitative histology of endomyocardial biopsies. Sixteen patients with presumptive diagnosis of cardiomyopathy were ultrasonically studied by means of an M-mode-based echocardiographic system with quantitative integrated backscatter analysis capabilities. A 2.25 MHz transducer was used. The integrated value of the rectified radiofrequency signal of the interventricular septum was taken as integrated backscatter index and expressed in percent normalized for the pericardial interface (assumed to be 100%). All patients also underwent multiple left ventricular endomyocardial biopsies, which were stained with Masson''s trichrome and studied with the use of a computer-assisted image analysis system. The percent integrated backscatter index was significantly higher in the presence of connective tissue area greater than 20% (eight patients) versus less than 20% (eight patients): 51 .+-. 25% versus 26 .+-. 11%, p < 0.05. A significant correlation (p < 0.05, R = 0.55) was found between percent integrated backscatter index and percent connective tissue area. In vivo on-line quantitative ultrasound analysis is feasible in man and reliably identifies variations in the regional extent of fibrosis in human myocardium.