Natural stimuli evoke dynamic sequences of states in sensory cortical ensembles
Natural stimuli evoke dynamic sequences of states in sensory cortical ensembles
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DOI：
10.1073/pnas.0705546104
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发表时间：
2007-11-20
影响因子：
11.1
通讯作者：
Katz, Donald B.
中科院分区：
文献类型：
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作者：
Jones, Lauren M.;Fontanini, Alfredo;Katz, Donald B.
虽然时间编码是神经生理学研究的一个常见主题，但时间编码中的试验间变异性通常被视为噪音，并被认为在感觉功能中不起作用。在这里，我们表明，这种所谓的“噪音”忠实地反映了在相干神经网络中进行的刺激相关的过程。皮质神经元对感觉刺激的反应是通过一系列状态来进行的，这些状态只有在同时记录的合奏中才能识别。合奏从一个州过渡到另一个州的具体时间因试验而异，但州序列是可靠的，刺激特异性的。因此，在状态序列方面的整体反应的表征捕获的感官处理的方面，从其他分析中缺失，并在模糊。这项工作提供的证据表明，感觉神经元作为一个系统级的动态过程的一部分，其性质可以通过观察分布式合奏最好的赞赏。
Although temporal coding is a frequent topic of neurophysiology research, trial-to-trial variability in temporal codes is typically dismissed as noise and thought to play no role in sensory function. Here, we show that much of this supposed "noise" faithfully reflects stimulus-related processes carried out in coherent neural networks. Cortical neurons responded to sensory stimuli by progressing through sequences of states, identifiable only in examinations of simultaneously recorded ensembles. The specific times at which ensembles transitioned from state to state varied from trial to trial, but the state sequences were reliable and stimulus-specific. Thus, the characterization of ensemble responses in terms of state sequences captured facets of sensory processing that are missing from, and obscured in, other analyses. This work provides evidence that sensory neurons act as parts of a systems-level dynamic process, the nature of which can best be appreciated through observation of distributed ensembles.